Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees

N. Ertekin-Taner, N. Graff-Radford, L. H. Younkin, C. Eckman, M. Baker, J. Adamson, J. Ronald, J. Blangero, M. Hutton, S. G. Younkin

Research output: Contribution to journalArticle

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Abstract

Plasma Aβ42 (amyloid β42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Aβ42, we used plasma Aβ42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high plasma Aβ. Here, we report linkage to chromosome 10 with a maximal lod score of 3.93 at 81 centimorgans close to D10S1225. Remarkably, linkage to the same region was obtained independently in a genome-wide screen of LOAD sibling pairs. These results provide strong evidence for a novel LOAD locus on chromosome 10 that acts to increase Aβ.

Original languageEnglish (US)
Pages (from-to)2303-2304
Number of pages2
JournalScience
Volume290
Issue number5500
DOIs
StatePublished - Dec 22 2000
Externally publishedYes

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Chromosomes, Human, Pair 10
Pedigree
Amyloid
Alzheimer Disease
Peptides
Lod Score
Siblings
Genome

ASJC Scopus subject areas

  • General

Cite this

Ertekin-Taner, N., Graff-Radford, N., Younkin, L. H., Eckman, C., Baker, M., Adamson, J., ... Younkin, S. G. (2000). Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science, 290(5500), 2303-2304. https://doi.org/10.1126/science.290.5500.2303

Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. / Ertekin-Taner, N.; Graff-Radford, N.; Younkin, L. H.; Eckman, C.; Baker, M.; Adamson, J.; Ronald, J.; Blangero, J.; Hutton, M.; Younkin, S. G.

In: Science, Vol. 290, No. 5500, 22.12.2000, p. 2303-2304.

Research output: Contribution to journalArticle

Ertekin-Taner, N, Graff-Radford, N, Younkin, LH, Eckman, C, Baker, M, Adamson, J, Ronald, J, Blangero, J, Hutton, M & Younkin, SG 2000, 'Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees', Science, vol. 290, no. 5500, pp. 2303-2304. https://doi.org/10.1126/science.290.5500.2303
Ertekin-Taner N, Graff-Radford N, Younkin LH, Eckman C, Baker M, Adamson J et al. Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science. 2000 Dec 22;290(5500):2303-2304. https://doi.org/10.1126/science.290.5500.2303
Ertekin-Taner, N. ; Graff-Radford, N. ; Younkin, L. H. ; Eckman, C. ; Baker, M. ; Adamson, J. ; Ronald, J. ; Blangero, J. ; Hutton, M. ; Younkin, S. G. / Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. In: Science. 2000 ; Vol. 290, No. 5500. pp. 2303-2304.
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