Linkage of essential hypertension to the angiotensinogen locus in Mexican Americans

Larry D. Atwood, Candace M. Kammerer, Paul B. Samollow, James E. Hixson, Robert E. Shade, Jean W. MacCluer

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Essential hypertension has been linked to a highly polymorphic marker at the angiotensinogen locus, and association with a polymorphism in this locus has been found in some populations. We tested the hypothesis that these same polymorphic markers are linked to essential hypertension in Mexican Americans. The data comprised a l the affected relative pairs in 46 extended families chosen at random from a low-income barrio in San Antonio. Specifically, we searched for linkage by testing for excessive marker alleles shared identical by decent (IBD) among hypertensive relative pairs. When women taking oral contraceptives or hormones were excluded, the affected relative pairs shared a significant excess of alleles IBD for the highly heterozygous GT repeat polymorphism (P=.038) and were marginally significant for the M235T variant (P=.079), which has a much lower heterozygosity (0.43 versus 0.85 for the GT repeat). We also assayed plasma levels of angiotensinogen and, using likelihood methods, found no significant association (P=.43) between plasma levels of angiotensinogen and M235T genotypes. These results support the linkage of essential hypertension to the angiotensinogen locus but do not indicate a specific role for the M235T variant.

Original languageEnglish (US)
Pages (from-to)326-330
Number of pages5
JournalHypertension
Volume30
Issue number3 I
StatePublished - Sep 1997
Externally publishedYes

Fingerprint

Angiotensinogen
Alleles
Oral Contraceptives
Genotype
Hormones
Essential Hypertension
Population

Keywords

  • Association
  • Genetics
  • Polymorphisms
  • Relative pair

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Atwood, L. D., Kammerer, C. M., Samollow, P. B., Hixson, J. E., Shade, R. E., & MacCluer, J. W. (1997). Linkage of essential hypertension to the angiotensinogen locus in Mexican Americans. Hypertension, 30(3 I), 326-330.

Linkage of essential hypertension to the angiotensinogen locus in Mexican Americans. / Atwood, Larry D.; Kammerer, Candace M.; Samollow, Paul B.; Hixson, James E.; Shade, Robert E.; MacCluer, Jean W.

In: Hypertension, Vol. 30, No. 3 I, 09.1997, p. 326-330.

Research output: Contribution to journalArticle

Atwood, LD, Kammerer, CM, Samollow, PB, Hixson, JE, Shade, RE & MacCluer, JW 1997, 'Linkage of essential hypertension to the angiotensinogen locus in Mexican Americans', Hypertension, vol. 30, no. 3 I, pp. 326-330.
Atwood LD, Kammerer CM, Samollow PB, Hixson JE, Shade RE, MacCluer JW. Linkage of essential hypertension to the angiotensinogen locus in Mexican Americans. Hypertension. 1997 Sep;30(3 I):326-330.
Atwood, Larry D. ; Kammerer, Candace M. ; Samollow, Paul B. ; Hixson, James E. ; Shade, Robert E. ; MacCluer, Jean W. / Linkage of essential hypertension to the angiotensinogen locus in Mexican Americans. In: Hypertension. 1997 ; Vol. 30, No. 3 I. pp. 326-330.
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