Linkage of cystic fibrosis to two tightly linked DNA markers: Joint report from a collaborative study

A. Beaudet, A. Bowcock, M. Buchwald, L. Cavalli-Sforza, M. Farrall, M. C. King, K. Klinger, J. M. Lalouel, G. Lathrop, S. Naylor

Research output: Contribution to journalArticlepeer-review

108 Scopus citations

Abstract

A collaborative study involving seven research groups provided an opportunity to investigate the linkage relationships between cystic fibrosis and two DNA marker loci, MET and pJ3.11 (D7S8), on an extended sample of 211 tested families. The maximum lod scores, recombination estimates, and confidence upper bounds (in parentheses) were 91.0 at Θ = .004 (.012) for CF and MET, 71.3 at Θ = .003 (.011) for CF and D7S8, and 69.3 at Θ = .018 (.036) for MET and D7S8. Three-locus analyses yielded best support for the order MET-CF-D7S8, with odds against the alternate orders CF-MET-D7S8 and CF-D7S8-MET of 9:1 and 161:1, respectively. However, the number of observed recombinants was small and only one of the recombinants was jointly informative for all three markers. Significant allelic association was found between CF and both MET and D7S8. Weaker association between the later two loci is consistent with the order MET-CF-D7S8.

Original languageEnglish (US)
Pages (from-to)681-693
Number of pages13
JournalAmerican Journal of Human Genetics
Volume39
Issue number6
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Fingerprint

Dive into the research topics of 'Linkage of cystic fibrosis to two tightly linked DNA markers: Joint report from a collaborative study'. Together they form a unique fingerprint.

Cite this