Linkage of cystic fibrosis locus and polymorphic DNA markers in 14 families

S. L. Naylor, D. R. Barnett, J. M. Buchanan, J. Latimer, K. Wieder, S. Marshall, J. Gardner, C. R. Denning, M. Gluckson, R. Pinero

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Linkage relationships between the cystic fibrosis (CF) locus and three polymorphic DNA markers were examined in 14 families, five of which were of Hispanic origin. Tight linkage was found between the CF locus and MET (maximum lod score = 7.16 at Θ = .001), and between CF and pJ3.11 (maximum lod score = 3.87 at Θ = .001). We observed two recombinations between CF and collagen, yielding a maximum lod score of 0.359 at Θ = .125, and one recombination in the cluster CF-MET-pJ3.11. Analysis by the seriation method indicates the order COL-pJ3.11-CF-MET.

Original languageEnglish (US)
Pages (from-to)707-712
Number of pages6
JournalAmerican Journal of Human Genetics
Volume39
Issue number6
StatePublished - 1986

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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