Linkage analysis has a long and successful history as a tool for localizing genes that shape human variation. This chapter provides a brief history of linkage analysis and an overview of linkage analysis methods used to map genes in human and nonhuman primate samples. The concepts behind linkage analysis are reviewed as basic approaches to Mendelian penetrance model-based, concordant and discordant sibling pair, and quantitative trait linkage. Examples of the successful application of these techniques in human and nonhuman primate studies are provided. Special challenges for linkage analysis in nonhuman primates and the role of linkage analysis in the whole genome sequence era are also discussed.
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)