Linkage heterogeneity between the C3 and LDLR and the APOA4 and APOA1 loci in baboons

Candace M. Kammerer; James E. Hixson; Mary Jo Aivaliotis; Patricia A. Porter; John L. VandeBerg

doi:10.1016/S0888-7543(05)80281-2

Linkage heterogeneity between the C3 and LDLR and the APOA4 and APOA1 loci in baboons

Candace M. Kammerer, James E. Hixson, Mary Jo Aivaliotis, Patricia A. Porter, John L. VandeBerg

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We detected linkage in baboons between loci for the third component of complement (C3) and the low-density lipoprotein receptor (LDLR), lod score = 5.53, and loci for apolipoprotein A1 (APOA1) and apolipoprotein AIV (APOA4), lod score = 14.59. We also found evidence for linkage heterogeneity among the baboon pedigrees between LDLR and C3 (P = 0.04) and between APOA1 and APOA4 (P = 0.01).

Original language	English (US)
Pages (from-to)	43-48
Number of pages	6
Journal	Genomics
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/S0888-7543(05)80281-2
State	Published - Sep 1992
Externally published	Yes

ASJC Scopus subject areas

Genetics

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title = "Linkage heterogeneity between the C3 and LDLR and the APOA4 and APOA1 loci in baboons",

abstract = "We detected linkage in baboons between loci for the third component of complement (C3) and the low-density lipoprotein receptor (LDLR), lod score = 5.53, and loci for apolipoprotein A1 (APOA1) and apolipoprotein AIV (APOA4), lod score = 14.59. We also found evidence for linkage heterogeneity among the baboon pedigrees between LDLR and C3 (P = 0.04) and between APOA1 and APOA4 (P = 0.01).",

author = "Kammerer, {Candace M.} and Hixson, {James E.} and Aivaliotis, {Mary Jo} and Porter, {Patricia A.} and VandeBerg, {John L.}",

note = "Funding Information: We thank L. A. Cox for typing the LDLR and APOA1 polymorphisms and J. A. Rogers for his comments in the preparation of this manuscript. This work was supported in part by NIH Grants HL-28972 and HG-00336 and NIH Contract HV-53030.",

year = "1992",

month = sep,

doi = "10.1016/S0888-7543(05)80281-2",

language = "English (US)",

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T1 - Linkage heterogeneity between the C3 and LDLR and the APOA4 and APOA1 loci in baboons

AU - Kammerer, Candace M.

AU - Hixson, James E.

AU - Aivaliotis, Mary Jo

AU - Porter, Patricia A.

AU - VandeBerg, John L.

N1 - Funding Information: We thank L. A. Cox for typing the LDLR and APOA1 polymorphisms and J. A. Rogers for his comments in the preparation of this manuscript. This work was supported in part by NIH Grants HL-28972 and HG-00336 and NIH Contract HV-53030.

PY - 1992/9

Y1 - 1992/9

N2 - We detected linkage in baboons between loci for the third component of complement (C3) and the low-density lipoprotein receptor (LDLR), lod score = 5.53, and loci for apolipoprotein A1 (APOA1) and apolipoprotein AIV (APOA4), lod score = 14.59. We also found evidence for linkage heterogeneity among the baboon pedigrees between LDLR and C3 (P = 0.04) and between APOA1 and APOA4 (P = 0.01).

AB - We detected linkage in baboons between loci for the third component of complement (C3) and the low-density lipoprotein receptor (LDLR), lod score = 5.53, and loci for apolipoprotein A1 (APOA1) and apolipoprotein AIV (APOA4), lod score = 14.59. We also found evidence for linkage heterogeneity among the baboon pedigrees between LDLR and C3 (P = 0.04) and between APOA1 and APOA4 (P = 0.01).

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JF - Genomics

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ER -

Linkage heterogeneity between the C3 and LDLR and the APOA4 and APOA1 loci in baboons

Abstract

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