Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus

Bernice Porjesz, Laura Almasy, Howard J. Edenberg, Kongming Wang, David B. Chorlian, Tatiana Foroud, Alison Goate, John P. Rice, Sean J. O'Connor, John Rohrbaugh, Samuel Kuperman, Lance O. Bauer, Raymond R. Crowe, Marc A. Schuckit, Victor Hesselbrock, P. Michael Conneally, Jay A. Tischfield, Ting Kai Li, Theodore Reich, Henri Begleiter

Research output: Contribution to journalArticle

228 Citations (Scopus)

Abstract

Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by γ-aminobutyric acid type A (GABAA) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABAA receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.

Original languageEnglish (US)
Pages (from-to)3729-3733
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number6
DOIs
StatePublished - Mar 19 2002
Externally publishedYes

Fingerprint

Aminobutyrates
Linkage Disequilibrium
Automatic Data Processing
Electroencephalography
Brain
Interneurons
Genetic Markers
Genes
Molecular Biology

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus. / Porjesz, Bernice; Almasy, Laura; Edenberg, Howard J.; Wang, Kongming; Chorlian, David B.; Foroud, Tatiana; Goate, Alison; Rice, John P.; O'Connor, Sean J.; Rohrbaugh, John; Kuperman, Samuel; Bauer, Lance O.; Crowe, Raymond R.; Schuckit, Marc A.; Hesselbrock, Victor; Conneally, P. Michael; Tischfield, Jay A.; Li, Ting Kai; Reich, Theodore; Begleiter, Henri.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 6, 19.03.2002, p. 3729-3733.

Research output: Contribution to journalArticle

Porjesz, B, Almasy, L, Edenberg, HJ, Wang, K, Chorlian, DB, Foroud, T, Goate, A, Rice, JP, O'Connor, SJ, Rohrbaugh, J, Kuperman, S, Bauer, LO, Crowe, RR, Schuckit, MA, Hesselbrock, V, Conneally, PM, Tischfield, JA, Li, TK, Reich, T & Begleiter, H 2002, 'Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus', Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 6, pp. 3729-3733. https://doi.org/10.1073/pnas.052716399
Porjesz, Bernice ; Almasy, Laura ; Edenberg, Howard J. ; Wang, Kongming ; Chorlian, David B. ; Foroud, Tatiana ; Goate, Alison ; Rice, John P. ; O'Connor, Sean J. ; Rohrbaugh, John ; Kuperman, Samuel ; Bauer, Lance O. ; Crowe, Raymond R. ; Schuckit, Marc A. ; Hesselbrock, Victor ; Conneally, P. Michael ; Tischfield, Jay A. ; Li, Ting Kai ; Reich, Theodore ; Begleiter, Henri. / Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus. In: Proceedings of the National Academy of Sciences of the United States of America. 2002 ; Vol. 99, No. 6. pp. 3729-3733.
@article{ec312e02e79d484b8b64c60aa5dbd81e,
title = "Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus",
abstract = "Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by γ-aminobutyric acid type A (GABAA) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABAA receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.",
author = "Bernice Porjesz and Laura Almasy and Edenberg, {Howard J.} and Kongming Wang and Chorlian, {David B.} and Tatiana Foroud and Alison Goate and Rice, {John P.} and O'Connor, {Sean J.} and John Rohrbaugh and Samuel Kuperman and Bauer, {Lance O.} and Crowe, {Raymond R.} and Schuckit, {Marc A.} and Victor Hesselbrock and Conneally, {P. Michael} and Tischfield, {Jay A.} and Li, {Ting Kai} and Theodore Reich and Henri Begleiter",
year = "2002",
month = "3",
day = "19",
doi = "10.1073/pnas.052716399",
language = "English (US)",
volume = "99",
pages = "3729--3733",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "6",

}

TY - JOUR

T1 - Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus

AU - Porjesz, Bernice

AU - Almasy, Laura

AU - Edenberg, Howard J.

AU - Wang, Kongming

AU - Chorlian, David B.

AU - Foroud, Tatiana

AU - Goate, Alison

AU - Rice, John P.

AU - O'Connor, Sean J.

AU - Rohrbaugh, John

AU - Kuperman, Samuel

AU - Bauer, Lance O.

AU - Crowe, Raymond R.

AU - Schuckit, Marc A.

AU - Hesselbrock, Victor

AU - Conneally, P. Michael

AU - Tischfield, Jay A.

AU - Li, Ting Kai

AU - Reich, Theodore

AU - Begleiter, Henri

PY - 2002/3/19

Y1 - 2002/3/19

N2 - Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by γ-aminobutyric acid type A (GABAA) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABAA receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.

AB - Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by γ-aminobutyric acid type A (GABAA) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABAA receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.

UR - http://www.scopus.com/inward/record.url?scp=18344368607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18344368607&partnerID=8YFLogxK

U2 - 10.1073/pnas.052716399

DO - 10.1073/pnas.052716399

M3 - Article

VL - 99

SP - 3729

EP - 3733

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 6

ER -