Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus

Bernice Porjesz, Laura Almasy, Howard J. Edenberg, Kongming Wang, David B. Chorlian, Tatiana Foroud, Alison Goate, John P. Rice, Sean J. O'Connor, John Rohrbaugh, Samuel Kuperman, Lance O. Bauer, Raymond R. Crowe, Marc A. Schuckit, Victor Hesselbrock, P. Michael Conneally, Jay A. Tischfield, Ting Kai Li, Theodore Reich, Henri Begleiter

Research output: Contribution to journalArticlepeer-review

243 Scopus citations


Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by γ-aminobutyric acid type A (GABAA) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABAA receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.

Original languageEnglish (US)
Pages (from-to)3729-3733
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number6
StatePublished - Mar 19 2002
Externally publishedYes

ASJC Scopus subject areas

  • General


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