Linkage analysis of albuminuria

Amy K. Mottl, Suma Vupputuri, Shelley A. Cole, Laura Almasy, Harald H H Göring, Vincent P. Diego, Sandra Laston, Nawar Shara, Elisa T. Lee, Lyle G. Best, Richard R. Fabsitz, Jean W. MacCluer, Jason G. Umans, Kari E. North

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

American Indians have a higher prevalence of albuminuria than the general population, likely resulting from a combination of environmental and genetic risk factors. To localize gene regions influencing variation in urinary albumin-to-creatinine ratio, we performed a linkage analysis and explored gene-by-diabetes, -hypertension, and -obesity interactions in a large cohort of American Indian families. We recruited >3600 individuals from 13 American Indian tribes from three centers (Arizona, North and South Dakota, and Oklahoma). We performed multipoint variance component linkage analysis in each center as well as in the entire cohort after controlling for center effects. We used two modeling strategies: Model 1 incorporated age, gender, and interaction terms; model 2 also controlled for diabetes, BP, body mass index, HDL, LDL, triglycerides, and smoking status. We evaluated interactions with diabetes, hypertension, and obesity using additive, interaction-specific linkage and stratified analyses. Loci suggestive for linkage to urinary albuminto-creatinine ratio included 1q, 6p, 9q, 18q, and 20p. Gene-by-diabetes interaction was present with a quantitative trait locus specific to the diabetic stratum in the Dakotas isolated on 18q21.2 to 21.3 using model 1 (logarithm of odds = 3.3). Gene-by-hypertension interaction was present with quantitative trait loci specific to the hypertensive stratum in the Dakotas on 7q21.11 using model 1 (logarithm of odds = 3.4) and 10q25.1 using model 2 (logarithm of odds = 3.3). These loci replicate findings from multiple other genome scans of kidney disease phenotypes with distinct populations and are worthy of further study.

Original languageEnglish (US)
Pages (from-to)1597-1606
Number of pages10
JournalJournal of the American Society of Nephrology
Volume20
Issue number7
DOIs
StatePublished - Jul 2009
Externally publishedYes

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Albuminuria
North American Indians
Quantitative Trait Loci
Hypertension
Genes
Creatinine
Obesity
Kidney Diseases
Population Groups
Population
Albumins
Body Mass Index
Smoking
Genome
Phenotype

ASJC Scopus subject areas

  • Nephrology

Cite this

Mottl, A. K., Vupputuri, S., Cole, S. A., Almasy, L., Göring, H. H. H., Diego, V. P., ... North, K. E. (2009). Linkage analysis of albuminuria. Journal of the American Society of Nephrology, 20(7), 1597-1606. https://doi.org/10.1681/ASN.2008080895

Linkage analysis of albuminuria. / Mottl, Amy K.; Vupputuri, Suma; Cole, Shelley A.; Almasy, Laura; Göring, Harald H H; Diego, Vincent P.; Laston, Sandra; Shara, Nawar; Lee, Elisa T.; Best, Lyle G.; Fabsitz, Richard R.; MacCluer, Jean W.; Umans, Jason G.; North, Kari E.

In: Journal of the American Society of Nephrology, Vol. 20, No. 7, 07.2009, p. 1597-1606.

Research output: Contribution to journalArticle

Mottl, AK, Vupputuri, S, Cole, SA, Almasy, L, Göring, HHH, Diego, VP, Laston, S, Shara, N, Lee, ET, Best, LG, Fabsitz, RR, MacCluer, JW, Umans, JG & North, KE 2009, 'Linkage analysis of albuminuria', Journal of the American Society of Nephrology, vol. 20, no. 7, pp. 1597-1606. https://doi.org/10.1681/ASN.2008080895
Mottl AK, Vupputuri S, Cole SA, Almasy L, Göring HHH, Diego VP et al. Linkage analysis of albuminuria. Journal of the American Society of Nephrology. 2009 Jul;20(7):1597-1606. https://doi.org/10.1681/ASN.2008080895
Mottl, Amy K. ; Vupputuri, Suma ; Cole, Shelley A. ; Almasy, Laura ; Göring, Harald H H ; Diego, Vincent P. ; Laston, Sandra ; Shara, Nawar ; Lee, Elisa T. ; Best, Lyle G. ; Fabsitz, Richard R. ; MacCluer, Jean W. ; Umans, Jason G. ; North, Kari E. / Linkage analysis of albuminuria. In: Journal of the American Society of Nephrology. 2009 ; Vol. 20, No. 7. pp. 1597-1606.
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