Limitations of 3-phenylpropionylglycine in early screening for medium-chain acyl-coenzyme A dehydrogenase deficiency

Ajay Bhala, Michael J. Bennett, Karin L. McGowan, Daniel E. Hale

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Screening for medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency by urinary 3-phenylproplonylglycine may not be reliable in early infancy because young infants are not colonized with adult-type colonic flora. In this study we delineated the microbes that produce 3-phenylpropionic acid, the precursor of 3-phenylpropionylglycine. We found that the use of some antibiotics may alter gut flora, thereby confounding this method of screening for MCAD deficiency.

Original languageEnglish (US)
Pages (from-to)100-103
Number of pages4
JournalThe Journal of Pediatrics
Volume122
Issue number1
DOIs
StatePublished - Jan 1993
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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