Limb development in Diplopodia4: A polydactylous mutation in the chicken

Jeffrey A. Maccabe, Astrida B. Maccabe, Ursula K. Abbott, John R. McCarrey

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

In a study of the polydactylous mutation of the domestic chicken, diplopodia4, we have found that the genetic lesion affects primarily the mesoderm and only secondarily the ectoderm. The effect of this mutant mesenchyme on overlying ectodermal ridge, either mutant or normal, is to thicken the ridge preaxially, leading to increased outgrowth and preaxial polydactylism. A “zone of polarizing activity” in the normal limb‐bud seems to have a role in the control of its anteroposterior polarity. We have examined diplopodia4 limb‐buds for polarizing activity and found it to be normal in its activity and distribution. These results suggest that the supernumerary outgrowth in the mutant limbs result from increased ridge maintenance activity by the mesoderm without a concomitant increase in the activity or distribution of the polarizing zone.

Original languageEnglish (US)
Pages (from-to)383-393
Number of pages11
JournalJournal of Experimental Zoology
Volume191
Issue number3
DOIs
StatePublished - Mar 1975
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology

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