Abstract
Aims Atherosclerosis is a chronic disease that, from its origin to its ultimate complications, involves inflammatory cells, inflammatory proteins, and inflammatory responses from vascular cells. It has been demonstrated that cytokine activities are under neuroendocrine control, in part exerted by the pineal gland through the circadian secretion of its main product melatonin. Melatonin is mainly released during the night, but the precise relationship between melatonin and the light/dark rhythm of interleukin-6 in patients with acute myocardial infarction is still unclear. Methods and results The study included 60 patients diagnosed with acute myocardial infarction and 60 healthy volunteers whose venous blood samples were collected at 09:00 h (light period) and 02:00 h (dark period). Our results demonstrate that interleukin-6 concentrations presented a light/dark pattern with mean serum concentrations being higher in the acute myocardial infarction group than in the control group (101.26±13.43 and 52.67±7.73pg/ml at 02:00 h, 41.93±5.90 and 22.98±4.49pg/ml at 09:00 h, respectively, p<0.05). Differences in the day/night changes in melatonin levels in control subjects (48.19±7. 82 at 02:00 h, 14.51±2.36 at 09:00 h, pg/ml) and acute myocardial infarction patients (25.97±3.90 at 02:00 h, 12.29±4.01 at 09:00 h, pg/ml) (p<0.05) were a result of a reduced nocturnal elevation of melatonin in the acute myocardial infarction group. Conclusions The current findings suggest that the circadian secretion of melatonin may be responsible at least in part for light/dark variations of endogenous interleukin-6 production in patients with acute myocardial infarction. In this study, the melatonin seems to have an anti-inflammatory effect.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 89-93 |
| Number of pages | 5 |
| Journal | Cytokine |
| Volume | 26 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 21 2004 |
| Externally published | Yes |
Fingerprint
Keywords
- Anti-inflammatory
- Interleukin
- Light-dark
- Melatonin
- Myocardial infarction
ASJC Scopus subject areas
- Endocrinology
- Molecular Biology
- Immunology
- Immunology and Allergy
Cite this
Light/dark patterns of interleukin-6 in relation to the pineal hormone melatonin in patients with acute myocardial infarction. / Dominguez-Rodriguez, Alberto; Abreu-Gonzalez, Pedro; Garcia, Martin; Ferrer, Julio; De La Rosa, Alejandro; Vargas, Manuel; Reiter, Russel J.
In: Cytokine, Vol. 26, No. 2, 21.04.2004, p. 89-93.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Light/dark patterns of interleukin-6 in relation to the pineal hormone melatonin in patients with acute myocardial infarction
AU - Dominguez-Rodriguez, Alberto
AU - Abreu-Gonzalez, Pedro
AU - Garcia, Martin
AU - Ferrer, Julio
AU - De La Rosa, Alejandro
AU - Vargas, Manuel
AU - Reiter, Russel J
PY - 2004/4/21
Y1 - 2004/4/21
N2 - Aims Atherosclerosis is a chronic disease that, from its origin to its ultimate complications, involves inflammatory cells, inflammatory proteins, and inflammatory responses from vascular cells. It has been demonstrated that cytokine activities are under neuroendocrine control, in part exerted by the pineal gland through the circadian secretion of its main product melatonin. Melatonin is mainly released during the night, but the precise relationship between melatonin and the light/dark rhythm of interleukin-6 in patients with acute myocardial infarction is still unclear. Methods and results The study included 60 patients diagnosed with acute myocardial infarction and 60 healthy volunteers whose venous blood samples were collected at 09:00 h (light period) and 02:00 h (dark period). Our results demonstrate that interleukin-6 concentrations presented a light/dark pattern with mean serum concentrations being higher in the acute myocardial infarction group than in the control group (101.26±13.43 and 52.67±7.73pg/ml at 02:00 h, 41.93±5.90 and 22.98±4.49pg/ml at 09:00 h, respectively, p<0.05). Differences in the day/night changes in melatonin levels in control subjects (48.19±7. 82 at 02:00 h, 14.51±2.36 at 09:00 h, pg/ml) and acute myocardial infarction patients (25.97±3.90 at 02:00 h, 12.29±4.01 at 09:00 h, pg/ml) (p<0.05) were a result of a reduced nocturnal elevation of melatonin in the acute myocardial infarction group. Conclusions The current findings suggest that the circadian secretion of melatonin may be responsible at least in part for light/dark variations of endogenous interleukin-6 production in patients with acute myocardial infarction. In this study, the melatonin seems to have an anti-inflammatory effect.
AB - Aims Atherosclerosis is a chronic disease that, from its origin to its ultimate complications, involves inflammatory cells, inflammatory proteins, and inflammatory responses from vascular cells. It has been demonstrated that cytokine activities are under neuroendocrine control, in part exerted by the pineal gland through the circadian secretion of its main product melatonin. Melatonin is mainly released during the night, but the precise relationship between melatonin and the light/dark rhythm of interleukin-6 in patients with acute myocardial infarction is still unclear. Methods and results The study included 60 patients diagnosed with acute myocardial infarction and 60 healthy volunteers whose venous blood samples were collected at 09:00 h (light period) and 02:00 h (dark period). Our results demonstrate that interleukin-6 concentrations presented a light/dark pattern with mean serum concentrations being higher in the acute myocardial infarction group than in the control group (101.26±13.43 and 52.67±7.73pg/ml at 02:00 h, 41.93±5.90 and 22.98±4.49pg/ml at 09:00 h, respectively, p<0.05). Differences in the day/night changes in melatonin levels in control subjects (48.19±7. 82 at 02:00 h, 14.51±2.36 at 09:00 h, pg/ml) and acute myocardial infarction patients (25.97±3.90 at 02:00 h, 12.29±4.01 at 09:00 h, pg/ml) (p<0.05) were a result of a reduced nocturnal elevation of melatonin in the acute myocardial infarction group. Conclusions The current findings suggest that the circadian secretion of melatonin may be responsible at least in part for light/dark variations of endogenous interleukin-6 production in patients with acute myocardial infarction. In this study, the melatonin seems to have an anti-inflammatory effect.
KW - Anti-inflammatory
KW - Interleukin
KW - Light-dark
KW - Melatonin
KW - Myocardial infarction
UR - http://www.scopus.com/inward/record.url?scp=1642619150&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1642619150&partnerID=8YFLogxK
U2 - 10.1016/j.cyto.2004.01.003
DO - 10.1016/j.cyto.2004.01.003
M3 - Article
VL - 26
SP - 89
EP - 93
JO - Cytokine
JF - Cytokine
SN - 1043-4666
IS - 2
ER -