Light, timing of biological rhythms, and chronodisruption in man

Thomas C. Erren, Russel J. Reiter, Claus Piekarski

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations


This paper reviews abundant evidence suggesting that causes and course of aging and cancers can be considered as being both light- and rhythm-related. We define chronodisruption as a relevant disturbance of orderly biological rhythms over days and seasons and years in man. Light is the primary external mediator and melatonin a primary internal intermediary of such disturbances, which can result in earlier deaths via premature aging and cancers. We conclude that experimental and epidemiological research can provide further insights into common denominators of these chronic processes and may offer novel and uniform targets for prevention.

Original languageEnglish (US)
Pages (from-to)485-494
Number of pages10
Issue number11
StatePublished - Nov 2003

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics


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