Light-mediated perturbations of circadian timing and cancer risk

A mechanistic analysis

Russel J Reiter, Dan Xian Tan, Thomas C. Erren, Lorena Fuentes-Broto, Sergio D. Paredes

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

In industrialized countries, certain types of cancer, most notably, breast and prostate, are more frequent than in poorly developed nations. This high cancer frequency is not explained by any of the conventional causes. Within the past decade, numerous reports have appeared that link light at night with an elevated cancer risk. The three major consequences of light at night are sleep deprivation, chronodisruption, and melatonin suppression. Each of these individually or in combination may contribute to the reported rise in certain types of cancer. In this article, the potential mechanisms underlying the basis of the elevated cancer risk are briefly discussed. Finally, if cancer is a consequence of excessive nighttime light, it is likely that other diseases/conditions may also be exaggerated by the widespread use of light after darkness onset.

Original languageEnglish (US)
Pages (from-to)354-360
Number of pages7
JournalIntegrative Cancer Therapies
Volume8
Issue number4
DOIs
StatePublished - 2009

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Light
Neoplasms
Developed Countries
Sleep Deprivation
Darkness
Melatonin
Prostate
Breast

Keywords

  • Cancer
  • Circadian rhythms
  • Light at night
  • Melatonin

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Oncology

Cite this

Light-mediated perturbations of circadian timing and cancer risk : A mechanistic analysis. / Reiter, Russel J; Tan, Dan Xian; Erren, Thomas C.; Fuentes-Broto, Lorena; Paredes, Sergio D.

In: Integrative Cancer Therapies, Vol. 8, No. 4, 2009, p. 354-360.

Research output: Contribution to journalArticle

Reiter, Russel J ; Tan, Dan Xian ; Erren, Thomas C. ; Fuentes-Broto, Lorena ; Paredes, Sergio D. / Light-mediated perturbations of circadian timing and cancer risk : A mechanistic analysis. In: Integrative Cancer Therapies. 2009 ; Vol. 8, No. 4. pp. 354-360.
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