Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the framingham heart study

Caroline S. Fox; Michael J. Pencina; Peter W.F. Wilson; Nina P. Paynter; Ramachandran S. Vasan; Ralph B. D'Agostino

doi:10.2337/dc08-0025

Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the framingham heart study

Caroline S. Fox, Michael J. Pencina, Peter W.F. Wilson, Nina P. Paynter, Ramachandran S. Vasan, Ralph B. D'Agostino

Research output: Contribution to journal › Article › peer-review

184 Scopus citations

Abstract

OBJECTIVE -We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes. RESEARCH DESIGN AND METHODS - Participants were drawn from the original and offspring cohorts of the Framingham Heart Study. Lifetime (30-year) risk of CVD was assessed using a modified Kaplan-Meier approach adjusting for the competing risk of death, beginning from age 50 years. RESULTS - Over 30 years, the lifetime risk of CVD among women with diabetes was 54.8% among normal-weight women and 78.8% among obese women. Among normal-weight men with diabetes, the lifetime risk of CVD was 78.6%, whereas it was 86.9% among obese men. CONCLUSIONS - The lifetime risk of CVD among individuals with diabetes is high, and this relationship is further accentuated with increasing adiposity.

Original language	English (US)
Pages (from-to)	1582-1584
Number of pages	3
Journal	Diabetes care
Volume	31
Issue number	8
DOIs	https://doi.org/10.2337/dc08-0025
State	Published - Aug 2008
Externally published	Yes

ASJC Scopus subject areas

Advanced and Specialized Nursing
Internal Medicine
Endocrinology, Diabetes and Metabolism

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10.2337/dc08-0025

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title = "Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the framingham heart study",

abstract = "OBJECTIVE -We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes. RESEARCH DESIGN AND METHODS - Participants were drawn from the original and offspring cohorts of the Framingham Heart Study. Lifetime (30-year) risk of CVD was assessed using a modified Kaplan-Meier approach adjusting for the competing risk of death, beginning from age 50 years. RESULTS - Over 30 years, the lifetime risk of CVD among women with diabetes was 54.8% among normal-weight women and 78.8% among obese women. Among normal-weight men with diabetes, the lifetime risk of CVD was 78.6%, whereas it was 86.9% among obese men. CONCLUSIONS - The lifetime risk of CVD among individuals with diabetes is high, and this relationship is further accentuated with increasing adiposity.",

author = "Fox, {Caroline S.} and Pencina, {Michael J.} and Wilson, {Peter W.F.} and Paynter, {Nina P.} and Vasan, {Ramachandran S.} and D'Agostino, {Ralph B.}",

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T1 - Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the framingham heart study

AU - Fox, Caroline S.

AU - Pencina, Michael J.

AU - Wilson, Peter W.F.

AU - Paynter, Nina P.

AU - Vasan, Ramachandran S.

AU - D'Agostino, Ralph B.

PY - 2008/8

Y1 - 2008/8

N2 - OBJECTIVE -We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes. RESEARCH DESIGN AND METHODS - Participants were drawn from the original and offspring cohorts of the Framingham Heart Study. Lifetime (30-year) risk of CVD was assessed using a modified Kaplan-Meier approach adjusting for the competing risk of death, beginning from age 50 years. RESULTS - Over 30 years, the lifetime risk of CVD among women with diabetes was 54.8% among normal-weight women and 78.8% among obese women. Among normal-weight men with diabetes, the lifetime risk of CVD was 78.6%, whereas it was 86.9% among obese men. CONCLUSIONS - The lifetime risk of CVD among individuals with diabetes is high, and this relationship is further accentuated with increasing adiposity.

AB - OBJECTIVE -We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes. RESEARCH DESIGN AND METHODS - Participants were drawn from the original and offspring cohorts of the Framingham Heart Study. Lifetime (30-year) risk of CVD was assessed using a modified Kaplan-Meier approach adjusting for the competing risk of death, beginning from age 50 years. RESULTS - Over 30 years, the lifetime risk of CVD among women with diabetes was 54.8% among normal-weight women and 78.8% among obese women. Among normal-weight men with diabetes, the lifetime risk of CVD was 78.6%, whereas it was 86.9% among obese men. CONCLUSIONS - The lifetime risk of CVD among individuals with diabetes is high, and this relationship is further accentuated with increasing adiposity.

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Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the framingham heart study

Abstract

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