Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the framingham heart study

Caroline S. Fox, Michael J. Pencina, Peter W.F. Wilson, Nina P. Paynter, Ramachandran S. Vasan, Ralph B. D'Agostino

Research output: Contribution to journalArticlepeer-review

175 Scopus citations

Abstract

OBJECTIVE -We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes. RESEARCH DESIGN AND METHODS - Participants were drawn from the original and offspring cohorts of the Framingham Heart Study. Lifetime (30-year) risk of CVD was assessed using a modified Kaplan-Meier approach adjusting for the competing risk of death, beginning from age 50 years. RESULTS - Over 30 years, the lifetime risk of CVD among women with diabetes was 54.8% among normal-weight women and 78.8% among obese women. Among normal-weight men with diabetes, the lifetime risk of CVD was 78.6%, whereas it was 86.9% among obese men. CONCLUSIONS - The lifetime risk of CVD among individuals with diabetes is high, and this relationship is further accentuated with increasing adiposity.

Original languageEnglish (US)
Pages (from-to)1582-1584
Number of pages3
JournalDiabetes care
Volume31
Issue number8
DOIs
StatePublished - Aug 2008
Externally publishedYes

ASJC Scopus subject areas

  • Advanced and Specialized Nursing
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Fingerprint

Dive into the research topics of 'Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the framingham heart study'. Together they form a unique fingerprint.

Cite this