Lifespan in captive baboons is heritable

Lisa J. Martin, Michael C. Mahaney, Anne M. Bronikowski, K. Dee Carey, Bennett Dyke, Anthony G. Comuzzie

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The effects of aging are evident in multiple organ systems, tissues, cell types, and molecules; all complex phenotypes affected by multiple shared and unique environmental factors and genes, which makes identifying the role of genetics in human aging difficult. Researchers have used yeast, nematodes, fruit flies, and mice to search for genes that influence the aging process. Given the phylogenetic distance and anatomic and physiologic dissimilarities of these organisms from humans, directly extrapolating these results to our species is problematic. However, nonhuman primates have a high degree of genetic, anatomic and physiologic similarity with humans and, thus, they may assist in the detection, characterization, and identification of genetic and environmental influences on human aging. Our goal is to demonstrate that effects of genes on variation in lifespan, a surrogate measure of aging, can be detected in a nonhuman primate species. Using variance component analysis, heritability of age at death was estimated to be 0.23±0.08 (P=0.0003) in 674 baboons from the Southwest Foundation for Biomedical Research (SFBR). This research demonstrates that lifespan is under partial genetic control. Given these findings, we believe that the baboon has potential as a model of human aging.

Original languageEnglish (US)
Pages (from-to)1461-1467
Number of pages7
JournalMechanisms of Ageing and Development
Volume123
Issue number11
DOIs
StatePublished - Sep 2002
Externally publishedYes

Fingerprint

Papio
Aging of materials
Primates
Genes
Medical Genetics
Diptera
Biomedical Research
Fruit
Analysis of Variance
Yeasts
Research Personnel
Fruits
Phenotype
Yeast
Research
Tissue
Molecules

Keywords

  • Aging
  • Genetics
  • Non-human primates
  • Variance component analysis

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

Martin, L. J., Mahaney, M. C., Bronikowski, A. M., Dee Carey, K., Dyke, B., & Comuzzie, A. G. (2002). Lifespan in captive baboons is heritable. Mechanisms of Ageing and Development, 123(11), 1461-1467. https://doi.org/10.1016/S0047-6374(02)00083-0

Lifespan in captive baboons is heritable. / Martin, Lisa J.; Mahaney, Michael C.; Bronikowski, Anne M.; Dee Carey, K.; Dyke, Bennett; Comuzzie, Anthony G.

In: Mechanisms of Ageing and Development, Vol. 123, No. 11, 09.2002, p. 1461-1467.

Research output: Contribution to journalArticle

Martin, LJ, Mahaney, MC, Bronikowski, AM, Dee Carey, K, Dyke, B & Comuzzie, AG 2002, 'Lifespan in captive baboons is heritable', Mechanisms of Ageing and Development, vol. 123, no. 11, pp. 1461-1467. https://doi.org/10.1016/S0047-6374(02)00083-0
Martin LJ, Mahaney MC, Bronikowski AM, Dee Carey K, Dyke B, Comuzzie AG. Lifespan in captive baboons is heritable. Mechanisms of Ageing and Development. 2002 Sep;123(11):1461-1467. https://doi.org/10.1016/S0047-6374(02)00083-0
Martin, Lisa J. ; Mahaney, Michael C. ; Bronikowski, Anne M. ; Dee Carey, K. ; Dyke, Bennett ; Comuzzie, Anthony G. / Lifespan in captive baboons is heritable. In: Mechanisms of Ageing and Development. 2002 ; Vol. 123, No. 11. pp. 1461-1467.
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