Lifespan extension in genetically modified mice

Warren Ladiges, Holly Van Remmen, John R Strong, Yuji Ikeno, Piper Treuting, Peter Rabinovitch, Arlan Richardson

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Major advances in aging research have been made by studying the effect of genetic modifications on the lifespan of organisms, such as yeast, invertebrates (worms and flies) and mice. Data from yeast and invertebrates have been the most plentiful because of the ease in which genetic manipulations can be made and the rapidity by which lifespan experiments can be performed. With the ultimate focus on advancing human health, testing genetic interventions in mammals is crucial, and the mouse has proven to be the mammal most amenable to this task. Lifespan studies in mice are resource intensive, requiring up to 4 years to complete. Therefore, it is critical that a set of scientifically-based criteria be followed to assure reliable results and establish statistically significant findings so other laboratories can replicate and build on the data. Only then will it be possible to confidently determine that the genetic modification extends lifespan and alters aging.

Original languageEnglish (US)
Pages (from-to)346-352
Number of pages7
JournalAging Cell
Volume8
Issue number4
DOIs
StatePublished - 2009

Fingerprint

Invertebrates
Mammals
Yeasts
Genetic Engineering
Diptera
Health
Research

ASJC Scopus subject areas

  • Cell Biology
  • Aging

Cite this

Ladiges, W., Van Remmen, H., Strong, J. R., Ikeno, Y., Treuting, P., Rabinovitch, P., & Richardson, A. (2009). Lifespan extension in genetically modified mice. Aging Cell, 8(4), 346-352. https://doi.org/10.1111/j.1474-9726.2009.00491.x

Lifespan extension in genetically modified mice. / Ladiges, Warren; Van Remmen, Holly; Strong, John R; Ikeno, Yuji; Treuting, Piper; Rabinovitch, Peter; Richardson, Arlan.

In: Aging Cell, Vol. 8, No. 4, 2009, p. 346-352.

Research output: Contribution to journalArticle

Ladiges, W, Van Remmen, H, Strong, JR, Ikeno, Y, Treuting, P, Rabinovitch, P & Richardson, A 2009, 'Lifespan extension in genetically modified mice', Aging Cell, vol. 8, no. 4, pp. 346-352. https://doi.org/10.1111/j.1474-9726.2009.00491.x
Ladiges, Warren ; Van Remmen, Holly ; Strong, John R ; Ikeno, Yuji ; Treuting, Piper ; Rabinovitch, Peter ; Richardson, Arlan. / Lifespan extension in genetically modified mice. In: Aging Cell. 2009 ; Vol. 8, No. 4. pp. 346-352.
@article{942884823c354fa18840b0114394866d,
title = "Lifespan extension in genetically modified mice",
abstract = "Major advances in aging research have been made by studying the effect of genetic modifications on the lifespan of organisms, such as yeast, invertebrates (worms and flies) and mice. Data from yeast and invertebrates have been the most plentiful because of the ease in which genetic manipulations can be made and the rapidity by which lifespan experiments can be performed. With the ultimate focus on advancing human health, testing genetic interventions in mammals is crucial, and the mouse has proven to be the mammal most amenable to this task. Lifespan studies in mice are resource intensive, requiring up to 4 years to complete. Therefore, it is critical that a set of scientifically-based criteria be followed to assure reliable results and establish statistically significant findings so other laboratories can replicate and build on the data. Only then will it be possible to confidently determine that the genetic modification extends lifespan and alters aging.",
author = "Warren Ladiges and {Van Remmen}, Holly and Strong, {John R} and Yuji Ikeno and Piper Treuting and Peter Rabinovitch and Arlan Richardson",
year = "2009",
doi = "10.1111/j.1474-9726.2009.00491.x",
language = "English (US)",
volume = "8",
pages = "346--352",
journal = "Aging Cell",
issn = "1474-9718",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Lifespan extension in genetically modified mice

AU - Ladiges, Warren

AU - Van Remmen, Holly

AU - Strong, John R

AU - Ikeno, Yuji

AU - Treuting, Piper

AU - Rabinovitch, Peter

AU - Richardson, Arlan

PY - 2009

Y1 - 2009

N2 - Major advances in aging research have been made by studying the effect of genetic modifications on the lifespan of organisms, such as yeast, invertebrates (worms and flies) and mice. Data from yeast and invertebrates have been the most plentiful because of the ease in which genetic manipulations can be made and the rapidity by which lifespan experiments can be performed. With the ultimate focus on advancing human health, testing genetic interventions in mammals is crucial, and the mouse has proven to be the mammal most amenable to this task. Lifespan studies in mice are resource intensive, requiring up to 4 years to complete. Therefore, it is critical that a set of scientifically-based criteria be followed to assure reliable results and establish statistically significant findings so other laboratories can replicate and build on the data. Only then will it be possible to confidently determine that the genetic modification extends lifespan and alters aging.

AB - Major advances in aging research have been made by studying the effect of genetic modifications on the lifespan of organisms, such as yeast, invertebrates (worms and flies) and mice. Data from yeast and invertebrates have been the most plentiful because of the ease in which genetic manipulations can be made and the rapidity by which lifespan experiments can be performed. With the ultimate focus on advancing human health, testing genetic interventions in mammals is crucial, and the mouse has proven to be the mammal most amenable to this task. Lifespan studies in mice are resource intensive, requiring up to 4 years to complete. Therefore, it is critical that a set of scientifically-based criteria be followed to assure reliable results and establish statistically significant findings so other laboratories can replicate and build on the data. Only then will it be possible to confidently determine that the genetic modification extends lifespan and alters aging.

UR - http://www.scopus.com/inward/record.url?scp=67651163661&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651163661&partnerID=8YFLogxK

U2 - 10.1111/j.1474-9726.2009.00491.x

DO - 10.1111/j.1474-9726.2009.00491.x

M3 - Article

C2 - 19485964

AN - SCOPUS:67651163661

VL - 8

SP - 346

EP - 352

JO - Aging Cell

JF - Aging Cell

SN - 1474-9718

IS - 4

ER -