LHRH-(1-5): a bioactive peptide regulating reproduction

James L. Roberts, Shaila K. Mani, Michael J. Woller, Marc J. Glucksman, T. John Wu

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Luteinizing hormone-releasing hormone-I (LHRH-I) was isolated from the mammalian hypothalamus and shown to be the primary regulator of reproduction through its initiation of pituitary gonadotropin release. Subsequently, it has also been shown to have non-pituitary actions. Although the regulation of LHRH-I synthesis and release has been extensively studied, there is additional evidence to suggest that processing of the peptide represents another layer of regulation. The focus of this review will be on evidence for the action of LHRH-(1-5), the pentapeptide metabolite of LHRH-I, in regulating LHRH-I synthesis, secretion and reproductive behavior. The involvement of LHRH-(1-5) in the control of aspects of reproduction might represent yet another level of regulatory complexity through neuropeptide processing.

Original languageEnglish (US)
Pages (from-to)386-392
Number of pages7
JournalTrends in Endocrinology and Metabolism
Issue number10
StatePublished - Dec 2007

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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