LHRH-(1-5): a bioactive peptide regulating reproduction

James L. Roberts; Shaila K. Mani; Michael J. Woller; Marc J. Glucksman; T. John Wu

doi:10.1016/j.tem.2007.09.005

LHRH-(1-5): a bioactive peptide regulating reproduction

James L. Roberts, Shaila K. Mani, Michael J. Woller, Marc J. Glucksman, T. John Wu

Pharmacology

Research output: Contribution to journal › Review article

20 Scopus citations

Abstract

Luteinizing hormone-releasing hormone-I (LHRH-I) was isolated from the mammalian hypothalamus and shown to be the primary regulator of reproduction through its initiation of pituitary gonadotropin release. Subsequently, it has also been shown to have non-pituitary actions. Although the regulation of LHRH-I synthesis and release has been extensively studied, there is additional evidence to suggest that processing of the peptide represents another layer of regulation. The focus of this review will be on evidence for the action of LHRH-(1-5), the pentapeptide metabolite of LHRH-I, in regulating LHRH-I synthesis, secretion and reproductive behavior. The involvement of LHRH-(1-5) in the control of aspects of reproduction might represent yet another level of regulatory complexity through neuropeptide processing.

Original language	English (US)
Pages (from-to)	386-392
Number of pages	7
Journal	Trends in Endocrinology and Metabolism
Volume	18
Issue number	10
DOIs	https://doi.org/10.1016/j.tem.2007.09.005
Publication status	Published - Dec 1 2007

Fingerprint

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

Cite this

Roberts, J. L., Mani, S. K., Woller, M. J., Glucksman, M. J., & Wu, T. J. (2007). LHRH-(1-5): a bioactive peptide regulating reproduction. Trends in Endocrinology and Metabolism, 18(10), 386-392. https://doi.org/10.1016/j.tem.2007.09.005

@article{2cec03071c494e9caa0b649a82a22db7,

title = "LHRH-(1-5): a bioactive peptide regulating reproduction",

abstract = "Luteinizing hormone-releasing hormone-I (LHRH-I) was isolated from the mammalian hypothalamus and shown to be the primary regulator of reproduction through its initiation of pituitary gonadotropin release. Subsequently, it has also been shown to have non-pituitary actions. Although the regulation of LHRH-I synthesis and release has been extensively studied, there is additional evidence to suggest that processing of the peptide represents another layer of regulation. The focus of this review will be on evidence for the action of LHRH-(1-5), the pentapeptide metabolite of LHRH-I, in regulating LHRH-I synthesis, secretion and reproductive behavior. The involvement of LHRH-(1-5) in the control of aspects of reproduction might represent yet another level of regulatory complexity through neuropeptide processing.",

author = "Roberts, {James L.} and Mani, {Shaila K.} and Woller, {Michael J.} and Glucksman, {Marc J.} and Wu, {T. John}",

year = "2007",

month = "12",

day = "1",

doi = "10.1016/j.tem.2007.09.005",

language = "English (US)",

volume = "18",

pages = "386--392",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

publisher = "Elsevier Inc.",

number = "10",

}

TY - JOUR

T1 - LHRH-(1-5)

T2 - a bioactive peptide regulating reproduction

AU - Roberts, James L.

AU - Mani, Shaila K.

AU - Woller, Michael J.

AU - Glucksman, Marc J.

AU - Wu, T. John

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Luteinizing hormone-releasing hormone-I (LHRH-I) was isolated from the mammalian hypothalamus and shown to be the primary regulator of reproduction through its initiation of pituitary gonadotropin release. Subsequently, it has also been shown to have non-pituitary actions. Although the regulation of LHRH-I synthesis and release has been extensively studied, there is additional evidence to suggest that processing of the peptide represents another layer of regulation. The focus of this review will be on evidence for the action of LHRH-(1-5), the pentapeptide metabolite of LHRH-I, in regulating LHRH-I synthesis, secretion and reproductive behavior. The involvement of LHRH-(1-5) in the control of aspects of reproduction might represent yet another level of regulatory complexity through neuropeptide processing.

AB - Luteinizing hormone-releasing hormone-I (LHRH-I) was isolated from the mammalian hypothalamus and shown to be the primary regulator of reproduction through its initiation of pituitary gonadotropin release. Subsequently, it has also been shown to have non-pituitary actions. Although the regulation of LHRH-I synthesis and release has been extensively studied, there is additional evidence to suggest that processing of the peptide represents another layer of regulation. The focus of this review will be on evidence for the action of LHRH-(1-5), the pentapeptide metabolite of LHRH-I, in regulating LHRH-I synthesis, secretion and reproductive behavior. The involvement of LHRH-(1-5) in the control of aspects of reproduction might represent yet another level of regulatory complexity through neuropeptide processing.

UR - http://www.scopus.com/inward/record.url?scp=36249030000&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36249030000&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2007.09.005

DO - 10.1016/j.tem.2007.09.005

M3 - Review article

C2 - 17997103

AN - SCOPUS:36249030000

VL - 18

SP - 386

EP - 392

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 10

ER -

Access to Document

10.1016/j.tem.2007.09.005