LHRH-(1-5): a bioactive peptide regulating reproduction

James L. Roberts; Shaila K. Mani; Michael J. Woller; Marc J. Glucksman; T. John Wu

doi:10.1016/j.tem.2007.09.005

LHRH-(1-5): a bioactive peptide regulating reproduction

James L. Roberts, Shaila K. Mani, Michael J. Woller, Marc J. Glucksman, T. John Wu

Pharmacology

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Luteinizing hormone-releasing hormone-I (LHRH-I) was isolated from the mammalian hypothalamus and shown to be the primary regulator of reproduction through its initiation of pituitary gonadotropin release. Subsequently, it has also been shown to have non-pituitary actions. Although the regulation of LHRH-I synthesis and release has been extensively studied, there is additional evidence to suggest that processing of the peptide represents another layer of regulation. The focus of this review will be on evidence for the action of LHRH-(1-5), the pentapeptide metabolite of LHRH-I, in regulating LHRH-I synthesis, secretion and reproductive behavior. The involvement of LHRH-(1-5) in the control of aspects of reproduction might represent yet another level of regulatory complexity through neuropeptide processing.

Original language	English (US)
Pages (from-to)	386-392
Number of pages	7
Journal	Trends in Endocrinology and Metabolism
Volume	18
Issue number	10
DOIs	https://doi.org/10.1016/j.tem.2007.09.005
State	Published - Dec 2007

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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title = "LHRH-(1-5): a bioactive peptide regulating reproduction",

abstract = "Luteinizing hormone-releasing hormone-I (LHRH-I) was isolated from the mammalian hypothalamus and shown to be the primary regulator of reproduction through its initiation of pituitary gonadotropin release. Subsequently, it has also been shown to have non-pituitary actions. Although the regulation of LHRH-I synthesis and release has been extensively studied, there is additional evidence to suggest that processing of the peptide represents another layer of regulation. The focus of this review will be on evidence for the action of LHRH-(1-5), the pentapeptide metabolite of LHRH-I, in regulating LHRH-I synthesis, secretion and reproductive behavior. The involvement of LHRH-(1-5) in the control of aspects of reproduction might represent yet another level of regulatory complexity through neuropeptide processing.",

author = "Roberts, {James L.} and Mani, {Shaila K.} and Woller, {Michael J.} and Glucksman, {Marc J.} and Wu, {T. John}",

note = "Funding Information: This work was supported by United States Public Health Service grants NS39892, RR19325 (M.J.G.), NS037421, DA016719 (J.L.R.), MH63954, MH57442 (S.K.M.), National Science Foundation grants IBN-0446112 (M.J.W.), IBN-0315023 and IOA-0544150 (T.J.W.), and Department of Defense grant CO85AO (T.J.W.). M.J.G. acknowledges the structural biology expertise of Dr Adam J. Stein (RFUMS/Chicago Medical School) for Figure 1 . The opinions or assertions contained herein are the private ones of the authors and are not to be considered official or as reflecting the views of the Department of Defense or the Uniformed University of the Health Sciences.",

year = "2007",

month = dec,

doi = "10.1016/j.tem.2007.09.005",

language = "English (US)",

volume = "18",

pages = "386--392",

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T2 - a bioactive peptide regulating reproduction

AU - Roberts, James L.

AU - Mani, Shaila K.

AU - Woller, Michael J.

AU - Glucksman, Marc J.

AU - Wu, T. John

N1 - Funding Information: This work was supported by United States Public Health Service grants NS39892, RR19325 (M.J.G.), NS037421, DA016719 (J.L.R.), MH63954, MH57442 (S.K.M.), National Science Foundation grants IBN-0446112 (M.J.W.), IBN-0315023 and IOA-0544150 (T.J.W.), and Department of Defense grant CO85AO (T.J.W.). M.J.G. acknowledges the structural biology expertise of Dr Adam J. Stein (RFUMS/Chicago Medical School) for Figure 1 . The opinions or assertions contained herein are the private ones of the authors and are not to be considered official or as reflecting the views of the Department of Defense or the Uniformed University of the Health Sciences.

PY - 2007/12

Y1 - 2007/12

N2 - Luteinizing hormone-releasing hormone-I (LHRH-I) was isolated from the mammalian hypothalamus and shown to be the primary regulator of reproduction through its initiation of pituitary gonadotropin release. Subsequently, it has also been shown to have non-pituitary actions. Although the regulation of LHRH-I synthesis and release has been extensively studied, there is additional evidence to suggest that processing of the peptide represents another layer of regulation. The focus of this review will be on evidence for the action of LHRH-(1-5), the pentapeptide metabolite of LHRH-I, in regulating LHRH-I synthesis, secretion and reproductive behavior. The involvement of LHRH-(1-5) in the control of aspects of reproduction might represent yet another level of regulatory complexity through neuropeptide processing.

AB - Luteinizing hormone-releasing hormone-I (LHRH-I) was isolated from the mammalian hypothalamus and shown to be the primary regulator of reproduction through its initiation of pituitary gonadotropin release. Subsequently, it has also been shown to have non-pituitary actions. Although the regulation of LHRH-I synthesis and release has been extensively studied, there is additional evidence to suggest that processing of the peptide represents another layer of regulation. The focus of this review will be on evidence for the action of LHRH-(1-5), the pentapeptide metabolite of LHRH-I, in regulating LHRH-I synthesis, secretion and reproductive behavior. The involvement of LHRH-(1-5) in the control of aspects of reproduction might represent yet another level of regulatory complexity through neuropeptide processing.

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LHRH-(1-5): a bioactive peptide regulating reproduction

Abstract

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