Lexical retrieval in discourse: An early indicator of Alzheimer's dementia

Seija Pekkala; Debra Wiener; Jayandra J. Himali; Alexa S. Beiser; Loraine K. Obler; Yulin Liu; Ann McKee; Sanford Auerbach; Sudha Seshadri; Philip A. Wolf; Rhoda Au

doi:10.3109/02699206.2013.815278

Lexical retrieval in discourse: An early indicator of Alzheimer's dementia

Seija Pekkala, Debra Wiener, Jayandra J. Himali, Alexa S. Beiser, Loraine K. Obler, Yulin Liu, Ann McKee, Sanford Auerbach, Sudha Seshadri, Philip A. Wolf, Rhoda Au

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

We examined the progression of lexical-retrieval deficits in individuals with neuropathologically determined Alzheimer's disease (AD; n=23) and a comparison group without criteria for AD (n=24) to determine whether linguistic changes were a significant marker of the disease. Our participants underwent multiple administrations of a neuropsychological battery, with initial administration occurring on average 16 years prior to death. The battery included the Boston Naming Test (BNT), a letter fluency task (FAS) and written description of the Cookie Theft Picture (CTP). Repeated measures analysis revealed that the AD-group showed progressively greater decline in FAS and CTP lexical performance than the comparison group. Cross-sectional time-specific group comparisons indicated that the CTP differentiated performance between the two groups at 7-9 years prior to death and FAS and BNT only at 2-4 years. These results suggest that lexical-retrieval deficits in written discourse serve as an early indicator of AD.

Original language	English (US)
Pages (from-to)	905-921
Number of pages	17
Journal	Clinical Linguistics and Phonetics
Volume	27
Issue number	12
DOIs	https://doi.org/10.3109/02699206.2013.815278
State	Published - 2013
Externally published	Yes

Keywords

Alzheimer's disease
Discourse
Early markers
Naming
Neuropathology

ASJC Scopus subject areas

Speech and Hearing
Language and Linguistics
Linguistics and Language

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10.3109/02699206.2013.815278

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title = "Lexical retrieval in discourse: An early indicator of Alzheimer's dementia",

abstract = "We examined the progression of lexical-retrieval deficits in individuals with neuropathologically determined Alzheimer's disease (AD; n=23) and a comparison group without criteria for AD (n=24) to determine whether linguistic changes were a significant marker of the disease. Our participants underwent multiple administrations of a neuropsychological battery, with initial administration occurring on average 16 years prior to death. The battery included the Boston Naming Test (BNT), a letter fluency task (FAS) and written description of the Cookie Theft Picture (CTP). Repeated measures analysis revealed that the AD-group showed progressively greater decline in FAS and CTP lexical performance than the comparison group. Cross-sectional time-specific group comparisons indicated that the CTP differentiated performance between the two groups at 7-9 years prior to death and FAS and BNT only at 2-4 years. These results suggest that lexical-retrieval deficits in written discourse serve as an early indicator of AD.",

keywords = "Alzheimer's disease, Discourse, Early markers, Naming, Neuropathology",

author = "Seija Pekkala and Debra Wiener and Himali, {Jayandra J.} and Beiser, {Alexa S.} and Obler, {Loraine K.} and Yulin Liu and Ann McKee and Sanford Auerbach and Sudha Seshadri and Wolf, {Philip A.} and Rhoda Au",

note = "Funding Information: This manuscript has been supported by the National Health Institute, National Heart, Lung, and Blood Institute N01-HC-25195, National Institute of Neurological Disorders and Stroke NS17950, and the National Institute of Aging AG08122, AG16495. The manuscript has also been supported by the Academy of Finland (S. Pekkala, project number 213023). The authors report no conflicts of interest.",

year = "2013",

doi = "10.3109/02699206.2013.815278",

language = "English (US)",

volume = "27",

pages = "905--921",

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T2 - An early indicator of Alzheimer's dementia

AU - Pekkala, Seija

AU - Wiener, Debra

AU - Himali, Jayandra J.

AU - Beiser, Alexa S.

AU - Obler, Loraine K.

AU - Liu, Yulin

AU - McKee, Ann

AU - Auerbach, Sanford

AU - Seshadri, Sudha

AU - Wolf, Philip A.

AU - Au, Rhoda

N1 - Funding Information: This manuscript has been supported by the National Health Institute, National Heart, Lung, and Blood Institute N01-HC-25195, National Institute of Neurological Disorders and Stroke NS17950, and the National Institute of Aging AG08122, AG16495. The manuscript has also been supported by the Academy of Finland (S. Pekkala, project number 213023). The authors report no conflicts of interest.

PY - 2013

Y1 - 2013

N2 - We examined the progression of lexical-retrieval deficits in individuals with neuropathologically determined Alzheimer's disease (AD; n=23) and a comparison group without criteria for AD (n=24) to determine whether linguistic changes were a significant marker of the disease. Our participants underwent multiple administrations of a neuropsychological battery, with initial administration occurring on average 16 years prior to death. The battery included the Boston Naming Test (BNT), a letter fluency task (FAS) and written description of the Cookie Theft Picture (CTP). Repeated measures analysis revealed that the AD-group showed progressively greater decline in FAS and CTP lexical performance than the comparison group. Cross-sectional time-specific group comparisons indicated that the CTP differentiated performance between the two groups at 7-9 years prior to death and FAS and BNT only at 2-4 years. These results suggest that lexical-retrieval deficits in written discourse serve as an early indicator of AD.

AB - We examined the progression of lexical-retrieval deficits in individuals with neuropathologically determined Alzheimer's disease (AD; n=23) and a comparison group without criteria for AD (n=24) to determine whether linguistic changes were a significant marker of the disease. Our participants underwent multiple administrations of a neuropsychological battery, with initial administration occurring on average 16 years prior to death. The battery included the Boston Naming Test (BNT), a letter fluency task (FAS) and written description of the Cookie Theft Picture (CTP). Repeated measures analysis revealed that the AD-group showed progressively greater decline in FAS and CTP lexical performance than the comparison group. Cross-sectional time-specific group comparisons indicated that the CTP differentiated performance between the two groups at 7-9 years prior to death and FAS and BNT only at 2-4 years. These results suggest that lexical-retrieval deficits in written discourse serve as an early indicator of AD.

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Lexical retrieval in discourse: An early indicator of Alzheimer's dementia

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Keywords

ASJC Scopus subject areas

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