Leukotriene C4 induces mesenteric hypoperfusion and intestinal intramural acidosis in pigs

Stephen M. Cohn, Keith L. Kruithoff, Heidie R. Rothschild, Hailong Wang, Jan B. Antonsson, Steven O. Heard, Mitchell P. Fink

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We examined the effect of intravenous infusion of graded doses of authentic leukotriene (LT) C4 on several physiological variables in pentobarbital-anesthetized immature swine. Mesenteric blood flow (Q̊sma) was measured using an ultrasonic flow probe and ileal intramucosal hydrogen ion concentration ([H+]I) was estimated tonometrically. Three groups were studied. Pigs in Group I (n = 6) were infused beginning at t = 0 min with increasing doses (0.03-1.0 μg/kg-min) of LTC4, each dose being administered for 10 min. Pigs in Group II (n = 6) were infused with LTC4 as above, but were pre- and post-treated with a specific sulfidopeptide LT receptor antagonist, LY203647 (30 mg/kg bolus and then 10 mg/kg-hr) beginning at t = -20 min. Pigs in Group III (n = 4) received only normal saline (5 ml/kg-h). Infusing LTC4 significantly decreased Q̊sma and mesenteric oxygen uptake and significantly increased ileal [H+]I. These changes were prevented by LY203647. These data support the idea that sulfidopeptide LT are capable of causing mesenteric ischemia and that this phenomenon can be blocked by LY203647.

Original languageEnglish (US)
Pages (from-to)303-307
Number of pages5
JournalJournal of Surgical Research
Volume50
Issue number4
DOIs
StatePublished - Apr 1991

ASJC Scopus subject areas

  • Surgery

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