TY - JOUR
T1 - Lesions of midline midbrain structures leave medial forebrain bundle self-stimulation intact
AU - Waraczynski, Meg
AU - Perkins, Mark
AU - Acheson, Ashley
N1 - Funding Information:
This work was supported by an NIMH FIRST grant #MH52588 to MW. The authors wish to thank Christian Dow, Michael Messina, Elizabeth Nicholls, Timothy Nokes, and Shawn Wilson for assistance in data collection and histology.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999/9
Y1 - 1999/9
N2 - Previous work with psychophysically-based collision methods and pharmacological manipulation suggests a role in medial forebrain bundle (MFB) self-stimulation for neurons lying along the midline between the cerebral hemispheres, in the mid- and/or hindbrain. Also, recently-proposed models of the anatomical substrate for medial forebrain bundle stimulation reward suggest that at least part of the directly-activated axons of this substrate arise from mid- and/or hindbrain somata, bifurcate, and send bilateral projections to the MFB of each hemisphere. Branches of these axons are thought to cross the midline at some point near the ventral tegmental area. This study examines the effects on MFB stimulation reward of lesioning midbrain structures that lie along the midline between hemispheres. In 13 rats, lesions of the median raphe, the decussation of the superior cerebellar peduncle, or the interpeduncular nucleus were all ineffective in altering the stimulation frequency required to maintain half-maximal levels of operant responding for stimulation reward. These results are discussed in terms of implications for recent models of the anatomical substrate for brain stimulation reward. Copyright (C) 1999 Elsevier Science B.V.
AB - Previous work with psychophysically-based collision methods and pharmacological manipulation suggests a role in medial forebrain bundle (MFB) self-stimulation for neurons lying along the midline between the cerebral hemispheres, in the mid- and/or hindbrain. Also, recently-proposed models of the anatomical substrate for medial forebrain bundle stimulation reward suggest that at least part of the directly-activated axons of this substrate arise from mid- and/or hindbrain somata, bifurcate, and send bilateral projections to the MFB of each hemisphere. Branches of these axons are thought to cross the midline at some point near the ventral tegmental area. This study examines the effects on MFB stimulation reward of lesioning midbrain structures that lie along the midline between hemispheres. In 13 rats, lesions of the median raphe, the decussation of the superior cerebellar peduncle, or the interpeduncular nucleus were all ineffective in altering the stimulation frequency required to maintain half-maximal levels of operant responding for stimulation reward. These results are discussed in terms of implications for recent models of the anatomical substrate for brain stimulation reward. Copyright (C) 1999 Elsevier Science B.V.
KW - A8 dopaminergic cell
KW - Interpeduncular nucleus
KW - Medial forebrain bundle
KW - Median raphe
KW - Retrorubral fields
KW - Reward
KW - Self-stimulation
KW - Superior cerebellar peduncle
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U2 - 10.1016/S0166-4328(99)00033-9
DO - 10.1016/S0166-4328(99)00033-9
M3 - Article
C2 - 10513585
AN - SCOPUS:0033198972
VL - 103
SP - 175
EP - 184
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
IS - 2
ER -