Lesions of midline midbrain structures leave medial forebrain bundle self-stimulation intact

Meg Waraczynski, Mark Perkins, Ashley Acheson

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Previous work with psychophysically-based collision methods and pharmacological manipulation suggests a role in medial forebrain bundle (MFB) self-stimulation for neurons lying along the midline between the cerebral hemispheres, in the mid- and/or hindbrain. Also, recently-proposed models of the anatomical substrate for medial forebrain bundle stimulation reward suggest that at least part of the directly-activated axons of this substrate arise from mid- and/or hindbrain somata, bifurcate, and send bilateral projections to the MFB of each hemisphere. Branches of these axons are thought to cross the midline at some point near the ventral tegmental area. This study examines the effects on MFB stimulation reward of lesioning midbrain structures that lie along the midline between hemispheres. In 13 rats, lesions of the median raphe, the decussation of the superior cerebellar peduncle, or the interpeduncular nucleus were all ineffective in altering the stimulation frequency required to maintain half-maximal levels of operant responding for stimulation reward. These results are discussed in terms of implications for recent models of the anatomical substrate for brain stimulation reward. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)175-184
Number of pages10
JournalBehavioural Brain Research
Issue number2
StatePublished - Sep 1999


  • A8 dopaminergic cell
  • Interpeduncular nucleus
  • Medial forebrain bundle
  • Median raphe
  • Retrorubral fields
  • Reward
  • Self-stimulation
  • Superior cerebellar peduncle

ASJC Scopus subject areas

  • Behavioral Neuroscience


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