Leptin concentrations and insulin sensitivity in normoglycemic men

S. M. Haffner, H. Miettinen, L. Mykkänen, P. Karhapää, D. L. Rainwater, M. Laakso

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Objective: Leptin is a hormone regulating weight in the mouse. Leptin regulates food intake and appetite. Leptin concentrations are increased in obese individuals suggesting resistance to its effect. However, there is considerable variability in leptin levels at each level of adiposity suggesting that environmental and genetic factors may regulate leptin concentrations. We examined whether subjects with decreased insulin sensitivity have increased leptin levels. Methods: We used a radioimmunoassay to measure serum leptin levels and the hyperinsulinemic euglycemic clamp (with indirect calorimetry) to measure insulin sensitivity in 87 normoglycemic relatively lean men. Results: Leptin levels were significantly correlated with fasting insulin (r = 0.58), insulin area (r = 0.45), overall (r = -0.57), non-oxidative (r = -0.51) and oxidative (r = -0.51) whole body glucose disposal (all P-values < 0.001). After adjustment for body mass index, leptin levels remained significantly correlated with fasting insulin (r = 0.44), insulin area (r = 0.40), overall (r = -0.40), non-oxidative (r = -0.28) and oxidative (r = -0.33) whole body glucose disposal although the magnitude of the associations was considerably decreased. Leptin levels were significantly related to insulin sensitivity in both less obese and more obese subjects. Conclusions: We conclude that leptin concentrations are related to insulin resistance and insulin concentrations in relatively lean normoglycemic men and these associations are to some extent independent of body mass index. Thus, subjects with insulin resistance may be relatively resistant to the effects of leptin.

Original languageEnglish (US)
Pages (from-to)393-399
Number of pages7
JournalInternational Journal of Obesity
Volume21
Issue number5
StatePublished - 1997
Externally publishedYes

Fingerprint

Leptin
leptin
insulin resistance
Insulin Resistance
insulin
Insulin
fasting
body mass index
Fasting
Body Mass Index
Glucose
Indirect Calorimetry
glucose
Glucose Clamp Technique
Adiposity
calorimetry
adiposity
Appetite
appetite
radioimmunoassays

Keywords

  • Insulin resistance
  • Leptin
  • Obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Haffner, S. M., Miettinen, H., Mykkänen, L., Karhapää, P., Rainwater, D. L., & Laakso, M. (1997). Leptin concentrations and insulin sensitivity in normoglycemic men. International Journal of Obesity, 21(5), 393-399.

Leptin concentrations and insulin sensitivity in normoglycemic men. / Haffner, S. M.; Miettinen, H.; Mykkänen, L.; Karhapää, P.; Rainwater, D. L.; Laakso, M.

In: International Journal of Obesity, Vol. 21, No. 5, 1997, p. 393-399.

Research output: Contribution to journalArticle

Haffner, SM, Miettinen, H, Mykkänen, L, Karhapää, P, Rainwater, DL & Laakso, M 1997, 'Leptin concentrations and insulin sensitivity in normoglycemic men', International Journal of Obesity, vol. 21, no. 5, pp. 393-399.
Haffner SM, Miettinen H, Mykkänen L, Karhapää P, Rainwater DL, Laakso M. Leptin concentrations and insulin sensitivity in normoglycemic men. International Journal of Obesity. 1997;21(5):393-399.
Haffner, S. M. ; Miettinen, H. ; Mykkänen, L. ; Karhapää, P. ; Rainwater, D. L. ; Laakso, M. / Leptin concentrations and insulin sensitivity in normoglycemic men. In: International Journal of Obesity. 1997 ; Vol. 21, No. 5. pp. 393-399.
@article{1030ce07eb9840e99d42759a503ab74d,
title = "Leptin concentrations and insulin sensitivity in normoglycemic men",
abstract = "Objective: Leptin is a hormone regulating weight in the mouse. Leptin regulates food intake and appetite. Leptin concentrations are increased in obese individuals suggesting resistance to its effect. However, there is considerable variability in leptin levels at each level of adiposity suggesting that environmental and genetic factors may regulate leptin concentrations. We examined whether subjects with decreased insulin sensitivity have increased leptin levels. Methods: We used a radioimmunoassay to measure serum leptin levels and the hyperinsulinemic euglycemic clamp (with indirect calorimetry) to measure insulin sensitivity in 87 normoglycemic relatively lean men. Results: Leptin levels were significantly correlated with fasting insulin (r = 0.58), insulin area (r = 0.45), overall (r = -0.57), non-oxidative (r = -0.51) and oxidative (r = -0.51) whole body glucose disposal (all P-values < 0.001). After adjustment for body mass index, leptin levels remained significantly correlated with fasting insulin (r = 0.44), insulin area (r = 0.40), overall (r = -0.40), non-oxidative (r = -0.28) and oxidative (r = -0.33) whole body glucose disposal although the magnitude of the associations was considerably decreased. Leptin levels were significantly related to insulin sensitivity in both less obese and more obese subjects. Conclusions: We conclude that leptin concentrations are related to insulin resistance and insulin concentrations in relatively lean normoglycemic men and these associations are to some extent independent of body mass index. Thus, subjects with insulin resistance may be relatively resistant to the effects of leptin.",
keywords = "Insulin resistance, Leptin, Obesity",
author = "Haffner, {S. M.} and H. Miettinen and L. Mykk{\"a}nen and P. Karhap{\"a}{\"a} and Rainwater, {D. L.} and M. Laakso",
year = "1997",
language = "English (US)",
volume = "21",
pages = "393--399",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Leptin concentrations and insulin sensitivity in normoglycemic men

AU - Haffner, S. M.

AU - Miettinen, H.

AU - Mykkänen, L.

AU - Karhapää, P.

AU - Rainwater, D. L.

AU - Laakso, M.

PY - 1997

Y1 - 1997

N2 - Objective: Leptin is a hormone regulating weight in the mouse. Leptin regulates food intake and appetite. Leptin concentrations are increased in obese individuals suggesting resistance to its effect. However, there is considerable variability in leptin levels at each level of adiposity suggesting that environmental and genetic factors may regulate leptin concentrations. We examined whether subjects with decreased insulin sensitivity have increased leptin levels. Methods: We used a radioimmunoassay to measure serum leptin levels and the hyperinsulinemic euglycemic clamp (with indirect calorimetry) to measure insulin sensitivity in 87 normoglycemic relatively lean men. Results: Leptin levels were significantly correlated with fasting insulin (r = 0.58), insulin area (r = 0.45), overall (r = -0.57), non-oxidative (r = -0.51) and oxidative (r = -0.51) whole body glucose disposal (all P-values < 0.001). After adjustment for body mass index, leptin levels remained significantly correlated with fasting insulin (r = 0.44), insulin area (r = 0.40), overall (r = -0.40), non-oxidative (r = -0.28) and oxidative (r = -0.33) whole body glucose disposal although the magnitude of the associations was considerably decreased. Leptin levels were significantly related to insulin sensitivity in both less obese and more obese subjects. Conclusions: We conclude that leptin concentrations are related to insulin resistance and insulin concentrations in relatively lean normoglycemic men and these associations are to some extent independent of body mass index. Thus, subjects with insulin resistance may be relatively resistant to the effects of leptin.

AB - Objective: Leptin is a hormone regulating weight in the mouse. Leptin regulates food intake and appetite. Leptin concentrations are increased in obese individuals suggesting resistance to its effect. However, there is considerable variability in leptin levels at each level of adiposity suggesting that environmental and genetic factors may regulate leptin concentrations. We examined whether subjects with decreased insulin sensitivity have increased leptin levels. Methods: We used a radioimmunoassay to measure serum leptin levels and the hyperinsulinemic euglycemic clamp (with indirect calorimetry) to measure insulin sensitivity in 87 normoglycemic relatively lean men. Results: Leptin levels were significantly correlated with fasting insulin (r = 0.58), insulin area (r = 0.45), overall (r = -0.57), non-oxidative (r = -0.51) and oxidative (r = -0.51) whole body glucose disposal (all P-values < 0.001). After adjustment for body mass index, leptin levels remained significantly correlated with fasting insulin (r = 0.44), insulin area (r = 0.40), overall (r = -0.40), non-oxidative (r = -0.28) and oxidative (r = -0.33) whole body glucose disposal although the magnitude of the associations was considerably decreased. Leptin levels were significantly related to insulin sensitivity in both less obese and more obese subjects. Conclusions: We conclude that leptin concentrations are related to insulin resistance and insulin concentrations in relatively lean normoglycemic men and these associations are to some extent independent of body mass index. Thus, subjects with insulin resistance may be relatively resistant to the effects of leptin.

KW - Insulin resistance

KW - Leptin

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=0030976609&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030976609&partnerID=8YFLogxK

M3 - Article

C2 - 9152742

AN - SCOPUS:0030976609

VL - 21

SP - 393

EP - 399

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 5

ER -