Left ventricular mechanical function: Clinical correlates, heritability, and association with parental heart failure

Susan Cheng, Elizabeth L. McCabe, Martin G. Larson, Ming Huei Chen, Ewa Osypiuk, Birgitta T. Lehman, Plamen Stantchev, Jayashri Aragam, Scott D. Solomon, Emelia J. Benjamin, Ramachandran S. Vasan

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Aims: Non-invasive measures of cardiac mechanical function may have the potential to serve as markers of risk for heart failure; however, limited data exist regarding clinical correlates and heritability of these measures in the community. Methods and results: We used speckle-tracking echocardiography to assess LV strain and synchrony in the Framingham Offspring Study (n = 2816; mean age 67 years, 54% women). In multivariable regression analyses, male gender (vs. female, P < 0.001), higher heart rate (P < 0.0001), and presence of cardiovascular disease (P < 0.001) were associated with worse global peak strains across all planes analysed (longitudinal, transverse, circumferential, and radial). Higher diastolic blood pressure and diabetes were associated with worse longitudinal strain (P < 0.01), and greater body mass index was associated with worse radial strain (P = 0.0004). Overall, however, clinical correlates accounted for only 4-19% of the variation in measures of LV mechanical function. Select measures of LV strain were heritable: longitudinal strain (h2 = 16%, P = 0.002), transverse strain (h2 = 15%, P = 0.006), and circumferential strain (h2 = 30%, P < 0.0001). Furthermore, in a subset of 1437 participants with parental data available, parental heart failure was associated with worse circumferential strain in the offspring free of heart failure (P = 0.01). Conclusions: Our investigation in a large community-based sample identified heritablity and clinical correlates of LV mechanical function, and highlighted an association of parental heart failure with worse global circumferential strain in offspring.

Original languageEnglish (US)
Pages (from-to)44-50
Number of pages7
JournalEuropean Journal of Heart Failure
Volume17
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Heart failure
  • Heritability
  • Myocardial strain

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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