Left ventricular emptying dynamics in patients with asymmetric septal hypertrophy and concentric hypertrophic cardiomyopathy

J. Peters, V. Bhargava, A. Johnson, L. Mangiardi, R. Slutsky

Research output: Contribution to journalArticle

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Abstract

We studied the dynamics of left ventricular (LV) emptying in 8 patients with asymmetric septal hypertrophy (ASH), 6 patients with concentric hypertrophic cardiomyopathy (CHC), and 6 normal controls. Four patients with ASH had resting systolic gradients >20 mmHg, all had significant post premature ventricular contraction (PVC) systolic pressure gradients. LV volume (V) was obtained by frame‐by‐frame analysis of cineangiograms. End‐diastolic volume was similar for all groups; end‐systolic volume was significantly less in ASH and CHC patients than in normals. Maximum dV/dt was similar in ASH and CHC, and significantly greater than normals. Total systolic contraction time (SCT), i.e., time from peak volume to last cine frame at minimum volume, was similar for all groups, but the time required to eject 90% of stroke volume (90%T), as a fraction of SCT, was shorter for ASH (0.52±0.07) and CHC patients (0.51 ±0.05) than normals (0.67±0.07) (p < 0.05 vs myopathy groups). In the sinus beat following a PVC, however, this ratio decreased significantly in normals and CHC patients, but did not change in ASH patients. We conclude that ASH and CHC have similar exaggerated systolic LV ejection dynamics in the basal state; the failure of ASH patients with post‐PVC systolic outflow gradient to reduce 90% T/SCT post PVC may reflect obstruction to LV emptying.

Original languageEnglish (US)
Pages (from-to)647-652
Number of pages6
JournalClinical Cardiology
Volume5
Issue number12
DOIs
StatePublished - Dec 1982
Externally publishedYes

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Keywords

  • concentric hypertrophic cardiomyopathy
  • idiopathic hypertrophic subaortic stenosis
  • left ventricular ejection

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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