Left-sided pancreatectomy: A multicenter comparison of laparoscopic and open approaches

David A. Kooby, Theresa Gillespie, David Bentrem, Attila Nakeeb, Max C. Schmidt, Nipun B. Merchant, Alex A. Parikh, Robert C.G. Martin, Charles R. Scoggins, Syed Ahmad, Hong Jin Kim, Jaemin Park, Fabian Johnston, Matthew J. Strouch, Alex Menze, Jennifer Rymer, Rebecca McClaine, Steven M. Strasberg, Mark S. Talamonti, Charles A. StaleyKelly M. McMasters, Andrew M. Lowy, Johnita Byrd-Sellers, William C. Wood, William G. Hawkins

Research output: Contribution to journalArticlepeer-review

323 Scopus citations


Objectives: To compare perioperative outcomes of laparoscopic left-sided pancreatectomy (LLP) with traditional open left-sided pancreatectomy (OLP) in a multicenter experience. Summary And Background Data: LLP is being performed more commonly with limited data comparing results with outcomes from OLP. Methods: Data from 8 centers were combined for all cases performed between 2002-2006. OLP and LLP cohorts were matched by age, American Society of Anesthesiologists, resected pancreas length, tumor size, and diagnosis. Multivariate analysis was performed using binary logistic regression. Results: Six hundred sixty-seven LPs were performed, with 159 (24%) attempted laparoscopically. Indications were solid lesion in 307 (46%), cystic in 295 (44%), and pancreatitis in 65 (10%) cases. Positive margins occurred in 51 (8%) cases, 335 (50%) had complications, and significant leaks occurred in 108 (16%). Conversion to OLP occurred in 20 (13%) of the LLPs. In the matched comparison, 200 OLPs were compared with 142 LLPs. There were no differences in positive margin rates (8% vs. 7%, P = 0.8), operative times (216 vs. 230 minutes, P = 0.3), or leak rates (18% vs. 11%, P = 0.1). LLP patients had lower average blood loss (357 vs. 588 mL, P < 0.01), fewer complications (40% vs. 57%, P < 0.01), and shorter hospital stays (5.9 vs. 9.0 days, P < 0.01). By MVA, LLP was an independent factor for shorter hospital stay (P < 0.01, odds ratio 0.33, 95% confidence interval 0.19-0.56). Conclusions: In selected patients, LLP is associated with less morbidity and shorter LOS than OLP. Pancreatic fistula rates are similar for OLP and LLP. LLP is appropriate for selected patients with left-sided pancreatic pathology.

Original languageEnglish (US)
Pages (from-to)438-443
Number of pages6
JournalAnnals of surgery
Issue number3
StatePublished - Sep 2008
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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