Layer-specific anatomical, physiological and functional MRI of the retina

Timothy Q. Duong, Machelle T. Pardue, Peter M. Thulé, Darin E. Olson, Haiying Cheng, Govind Nair, Yingxia Li, Moon Kim, Xiaodong Zhang, Qiang Shen

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations

Abstract

Most retinal imaging has been performed using optical techniques. This paper reviews alternative retinal imaging methods based on MRI performed with spatial resolution sufficient to resolve multiple well-defined retinal layers. The development of these MRI technologies to study retinal anatomy, physiology (blood flow, blood volume, and oxygenation) and function, and their applications to the study of normal retinas, retinal degeneration and diabetic retinopathy in animal models are discussed. Although the spatiotemporal resolution of MRI is poorer than that of optical imaging techniques, it is unhampered by media opacity and can thus image all retinal and pararetinal structures, and has the potential to provide multiple unique clinically relevant data in a single setting and could thus complement existing retinal imaging techniques. In turn, the highly structured retina with well-defined layers is an excellent model for advancing emerging high-resolution anatomical, physiological and functional MRI technologies.

Original languageEnglish (US)
Pages (from-to)978-996
Number of pages19
JournalNMR in Biomedicine
Volume21
Issue number9
DOIs
StatePublished - 2008

Keywords

  • BOLD
  • Choroid
  • Diffusion-weighted MRI
  • Functional MRI
  • High resolution imaging
  • Manganese-enhanced MRI (MEMRI)
  • Retinal blood flow
  • Retinal diseases

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

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