Lateralization of membrane-associated protein kinase C in rat piriform cortex: Specific to operant training cues in the olfactory modality

James L. Olds, Upinder S. Bhalla, Donna L. McPhie, David S. Lester, James M. Bower, Daniel L. Alkon

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Rats were trained on an olfactory and a control modality (auditory or visual) discrimination task and brain membrane-associated protein kinase C (mPKC) was subsequently assessed using quantitative autoradiography of radiolabelled phorbol ester binding. In rats which received olfactory-cued training, mPKC showed a highly significant lateralization in the piriform cortex but not in the hippocampus. Both olfactory-trained rats and control modality rats showed a significant increase in mPKC in the hippocampus when compared to naive rats. Thus, while behavioral training procedures appeared to result in a hippocampal increase in the activated state of this enzyme as has been reported elsewhere, only olfactory learning produced an piriform cortex lateralization in the activated state of the enzyme. While the functional significance of such a change in the distribution of protein kinase C is still unclear, it does suggest that the monitoring of this enzyme's activational state may prove to be a useful tool in the study of memory formation in a wide variety of behavioral contexts.

Original languageEnglish (US)
Pages (from-to)37-46
Number of pages10
JournalBehavioural Brain Research
Volume61
Issue number1
DOIs
StatePublished - Mar 31 1994
Externally publishedYes

Fingerprint

Protein Kinase C
Cues
Membrane Proteins
Hippocampus
Enzymes
Phorbol Esters
Autoradiography
Piriform Cortex
Learning
Brain

Keywords

  • Learning
  • Memory
  • Piriform cortex
  • Protein kinase C

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Lateralization of membrane-associated protein kinase C in rat piriform cortex : Specific to operant training cues in the olfactory modality. / Olds, James L.; Bhalla, Upinder S.; McPhie, Donna L.; Lester, David S.; Bower, James M.; Alkon, Daniel L.

In: Behavioural Brain Research, Vol. 61, No. 1, 31.03.1994, p. 37-46.

Research output: Contribution to journalArticle

Olds, James L. ; Bhalla, Upinder S. ; McPhie, Donna L. ; Lester, David S. ; Bower, James M. ; Alkon, Daniel L. / Lateralization of membrane-associated protein kinase C in rat piriform cortex : Specific to operant training cues in the olfactory modality. In: Behavioural Brain Research. 1994 ; Vol. 61, No. 1. pp. 37-46.
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