Latent space arc therapy optimization

Noah Bice, Mohamad Fakhreddine, Ruiqi Li, Dan Nguyen, Christopher Kabat, Pamela Myers, Niko Papanikolaou, Neil Kirby

Research output: Contribution to journalArticlepeer-review


Volumetric modulated arc therapy planning is a challenging problem in high-dimensional, nonconvex optimization. Traditionally, heuristics such as fluence-map-optimization-informed segment initialization use locally optimal solutions to begin the search of the full arc therapy plan space from a reasonable starting point. These routines facilitate arc therapy optimization such that clinically satisfactory radiation treatment plans can be created in a reasonable time frame. However, current optimization algorithms favor solutions near their initialization point and are slower than necessary due to plan overparameterization. In this work, arc therapy overparameterization is addressed by reducing the effective dimension of treatment plans with unsupervised deep learning. An optimization engine is then built based on low-dimensional arc representations which facilitates faster planning times.

Original languageEnglish (US)
Article number215019
JournalPhysics in Medicine and Biology
Issue number21
StatePublished - Nov 7 2021


  • Deep learning
  • Optimization
  • VMAT

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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