Late recurrence of Wegener's granulomatosis presenting as tracheal stenosis in a renal transplant patient

S. A. Boubenider, M. Akhtar, O. Alfurayh, S. Algazlan, K. Taibah, Wajeh Y Qunibi

Research output: Contribution to journalArticle

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Abstract

An unusual case of a 46-year-old man who had end-stage renal disease due to crescentic glomerulonephritis that was treated by a cadaveric renal allograft is presented. About 18 months post-Tx, the patient developed severe tracheal stenosis which, on biopsy, revealed granulation tissue and chronic inflammation. After another 18 months he developed necrotizing glomerulonephritis involving the renal allograft and an inflammatory retro-orbital pseudotumor. The latter, on biopsy, revealed granulomatous vasculitis characteristic of Wegener's granulomatosis. This diagnosis was further confirmed by strongly positive anti-neutrophil antibodies with diffuse granular cytoplasmic immunofluorescence (C-ANCA). The patient was treated successfully with cyclophosphamide therapy.

Original languageEnglish (US)
Pages (from-to)5-9
Number of pages5
JournalClinical Transplantation
Volume8
Issue number1
StatePublished - 1994
Externally publishedYes

Fingerprint

Tracheal Stenosis
Granulomatosis with Polyangiitis
Glomerulonephritis
Allografts
Orbital Pseudotumor
Transplants
Kidney
Biopsy
Recurrence
Antineutrophil Cytoplasmic Antibodies
Granulation Tissue
Vasculitis
Cyclophosphamide
Chronic Kidney Failure
Fluorescent Antibody Technique
Anti-Idiotypic Antibodies
Neutrophils
Inflammation
Therapeutics

Keywords

  • ANCA
  • Necrotizing glomerulonephritis
  • Recurrence
  • Renal transplantation
  • Retro-orbital pseudotumor
  • Tracheal stenosis
  • Wegener's granulomatosis

ASJC Scopus subject areas

  • Immunology
  • Transplantation

Cite this

Boubenider, S. A., Akhtar, M., Alfurayh, O., Algazlan, S., Taibah, K., & Qunibi, W. Y. (1994). Late recurrence of Wegener's granulomatosis presenting as tracheal stenosis in a renal transplant patient. Clinical Transplantation, 8(1), 5-9.

Late recurrence of Wegener's granulomatosis presenting as tracheal stenosis in a renal transplant patient. / Boubenider, S. A.; Akhtar, M.; Alfurayh, O.; Algazlan, S.; Taibah, K.; Qunibi, Wajeh Y.

In: Clinical Transplantation, Vol. 8, No. 1, 1994, p. 5-9.

Research output: Contribution to journalArticle

Boubenider, SA, Akhtar, M, Alfurayh, O, Algazlan, S, Taibah, K & Qunibi, WY 1994, 'Late recurrence of Wegener's granulomatosis presenting as tracheal stenosis in a renal transplant patient', Clinical Transplantation, vol. 8, no. 1, pp. 5-9.
Boubenider SA, Akhtar M, Alfurayh O, Algazlan S, Taibah K, Qunibi WY. Late recurrence of Wegener's granulomatosis presenting as tracheal stenosis in a renal transplant patient. Clinical Transplantation. 1994;8(1):5-9.
Boubenider, S. A. ; Akhtar, M. ; Alfurayh, O. ; Algazlan, S. ; Taibah, K. ; Qunibi, Wajeh Y. / Late recurrence of Wegener's granulomatosis presenting as tracheal stenosis in a renal transplant patient. In: Clinical Transplantation. 1994 ; Vol. 8, No. 1. pp. 5-9.
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