Late effects of low-energy gamma-emitting stents in a rabbit iliac artery model

Bradley H. Strauss, Chris Li, Heather A. Whittingham, Fermin O. Tio, M. J.B. Kutryk, Christian Janicki, John D. Sparkes, Todd Turnlund, William L. Sweet

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Purpose: To determine the long-term dose response of novel low-dose γ-emitting stents in a rabbit iliac artery model. Methods and Materials: Control stents (n=24) and 103Pd stents 1.0 to 4.0 mCi (n=36) were implanted in the iliac arteries of 30 New Zealand rabbits. Stents were evaluated by intravascular ultrasound (immediately post procedure and before killing) and by histomorphometry. Results: At 26 weeks, 28 rabbits were killed, with no evidence of stent thrombosis. In the body of the stent there was a dose-response relationship with 50% inhibition of intimal hyperplasia at the highest activity compared to control stents (p=0.07) and a significant increase in intimal hyperplasia at the lowest activity (p < 0.01). At the stent edges, there was a significant reduction of lumen area at all activity levels compared to control stents, which was most prominent at the proximal stent edge. Higher-activity stents demonstrated incomplete endothelialization and immature neointimal formation. Conclusions: Continuous low-dose-rate irradiation by γ-emitting 103Pd stents is feasible with reduction of in-stent hyperplasia in a dose-related manner. However, significant narrowing at the stent edges, increased in-stent hyperplasia at lower activities, and incomplete vascular healing with persistence of immature neointima at higher activities are significant limitations.

Original languageEnglish (US)
Pages (from-to)551-561
Number of pages11
JournalInternational Journal of Radiation Oncology Biology Physics
Volume54
Issue number2
DOIs
StatePublished - Oct 1 2002

Keywords

  • Coronary disease
  • Intravascular ultrasound
  • Palladium
  • Radiation
  • Restenosis
  • Stents

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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