Laser angioplasty using a lensed-fiber delivery system and a pulsed Nd-YAG laser. Early clinical results

Christopher J. White, Stephen R. Ramee, Juan E. Mesa, Larry H. Hollier, Joseph P Murgo, Michael Aita, Gene Samson, Maureen Godfrey

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We performed a clinical trial to evaluate the safety and efficacy of a unique lensed-fiber delivery system with a pulsed Neodymium-yttrium aluminum garnet (Nd-YAG) laser in patients with atherosclerotic peripheral vascular disease. The lensed-fiber consists of a spherical silica lens, 1.5 mm in diameter, mounted at the distal tip of a 300 μm silica optical fiber. The Nd-YAG laser is pulsed at 10 Hz, and we delivered 0.5 J/pulse with a pulse duration of 100 msecs in 2- to 5-second bursts. Successful recanalization of stenoses or occlusions was obtained in 9 of 10 patients and was manifested by improvement in blood flow as measured angiographically and with ankle-brachial blood pressure index improvement (> 0.15). There were no arterial perforations or dissections associated with the laser angioplasty. All successfully recanalized patients required adjunctive balloon angioplasty to obtain a satisfactory reduction in luminal diameter stenosis of the treated artery. We conclude that this unique delivery system and the pulsed Nd-YAG laser are a safe and effective method of recanalizing arterial stenoses not amendable to conventional balloon angioplasty alone.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsAbraham Katzir
Place of PublicationBellingham, WA, United States
PublisherPubl by Int Soc for Optical Engineering
Pages206-210
Number of pages5
Volume1201
ISBN (Print)0819402427
StatePublished - 1990
Externally publishedYes
EventProceedings of Optical Fibers in Medicine V - Los Angeles, CA, USA
Duration: Jan 14 1990Jan 19 1990

Other

OtherProceedings of Optical Fibers in Medicine V
CityLos Angeles, CA, USA
Period1/14/901/19/90

Fingerprint

Neodymium
Garnets
neodymium
Yttrium
yttrium-aluminum garnet
delivery
Balloons
balloons
Aluminum
fibers
Fibers
Lasers
Silica
silicon dioxide
lasers
blood pressure
Dissection
dissection
perforation
occlusion

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

White, C. J., Ramee, S. R., Mesa, J. E., Hollier, L. H., Murgo, J. P., Aita, M., ... Godfrey, M. (1990). Laser angioplasty using a lensed-fiber delivery system and a pulsed Nd-YAG laser. Early clinical results. In A. Katzir (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1201, pp. 206-210). Bellingham, WA, United States: Publ by Int Soc for Optical Engineering.

Laser angioplasty using a lensed-fiber delivery system and a pulsed Nd-YAG laser. Early clinical results. / White, Christopher J.; Ramee, Stephen R.; Mesa, Juan E.; Hollier, Larry H.; Murgo, Joseph P; Aita, Michael; Samson, Gene; Godfrey, Maureen.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / Abraham Katzir. Vol. 1201 Bellingham, WA, United States : Publ by Int Soc for Optical Engineering, 1990. p. 206-210.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

White, CJ, Ramee, SR, Mesa, JE, Hollier, LH, Murgo, JP, Aita, M, Samson, G & Godfrey, M 1990, Laser angioplasty using a lensed-fiber delivery system and a pulsed Nd-YAG laser. Early clinical results. in A Katzir (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 1201, Publ by Int Soc for Optical Engineering, Bellingham, WA, United States, pp. 206-210, Proceedings of Optical Fibers in Medicine V, Los Angeles, CA, USA, 1/14/90.
White CJ, Ramee SR, Mesa JE, Hollier LH, Murgo JP, Aita M et al. Laser angioplasty using a lensed-fiber delivery system and a pulsed Nd-YAG laser. Early clinical results. In Katzir A, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1201. Bellingham, WA, United States: Publ by Int Soc for Optical Engineering. 1990. p. 206-210
White, Christopher J. ; Ramee, Stephen R. ; Mesa, Juan E. ; Hollier, Larry H. ; Murgo, Joseph P ; Aita, Michael ; Samson, Gene ; Godfrey, Maureen. / Laser angioplasty using a lensed-fiber delivery system and a pulsed Nd-YAG laser. Early clinical results. Proceedings of SPIE - The International Society for Optical Engineering. editor / Abraham Katzir. Vol. 1201 Bellingham, WA, United States : Publ by Int Soc for Optical Engineering, 1990. pp. 206-210
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