Abstract
Emerging technologies allow broad profiling of the cancer genome for differential DNA methylation relative to benign cells. Herein, bisulfite-modified DNA from lymph nodes with either reactive hyperplasia or follicular lymphoma (FL) were analyzed using a commercial C/UpG genotyping assay. Two hundred fifty-nine differentially methylated targets (DMT) distributed among 183 unique genes were identified in FL. Comparison of matched formalin-fixed, paraffin-embedded and frozen surgical pathology replicates showed the complete preservation of the cancer methylome among differently archived tissue specimens. Analysis of the DMT profile is consistent with a pervasive epigenomic remodeling process in FLthat affects predominantly nonlymphoid genes.
Original language | English (US) |
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Pages (from-to) | 758-764 |
Number of pages | 7 |
Journal | Cancer Research |
Volume | 69 |
Issue number | 3 |
DOIs | |
State | Published - Feb 1 2009 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research