TY - JOUR
T1 - Langerhans Cell Histiocytosis in an Adult
T2 - A Discussion of Epidemiology and Treatment Options
AU - El-Arab, Kaley K.
AU - Luedke, Alexis Inge
AU - Julian, Bao Quynh Thuy
AU - Ferrauiola, Julie
AU - Miller, Frank Raymond
AU - Wang, Howard Tz Ho
N1 - Publisher Copyright:
© 2019 by Mutaz B. Habal, MD.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Langerhans cell histiocytosis (LCH) is a rare disorder defined by the abnormal proliferation of Langerhans cells. While LCH can present at any age, it is classically described as a pediatric condition, and is therefore overlooked in the adult patient. Additionally, depending on tumor burden and location, LCH can manifest with a host of oral and systemic symptoms which further confuses the clinical presentation and ultimate diagnosis.The authors present a unique report of an elderly Hispanic male diagnosed with mandibular LCH who sought primary tumor excision after neoadjuvant chemotherapy. In this study, a fibula-free flap was used for subsequent reconstruction.The purpose of the study is 2-fold: To highlight the variability of LCH in both patient symptomatology and demographics, as well as the role of plastic reconstructive surgery in definitive LCH management, particularly in the setting of single system unifocal disease.
AB - Langerhans cell histiocytosis (LCH) is a rare disorder defined by the abnormal proliferation of Langerhans cells. While LCH can present at any age, it is classically described as a pediatric condition, and is therefore overlooked in the adult patient. Additionally, depending on tumor burden and location, LCH can manifest with a host of oral and systemic symptoms which further confuses the clinical presentation and ultimate diagnosis.The authors present a unique report of an elderly Hispanic male diagnosed with mandibular LCH who sought primary tumor excision after neoadjuvant chemotherapy. In this study, a fibula-free flap was used for subsequent reconstruction.The purpose of the study is 2-fold: To highlight the variability of LCH in both patient symptomatology and demographics, as well as the role of plastic reconstructive surgery in definitive LCH management, particularly in the setting of single system unifocal disease.
KW - Bone lesion
KW - Langerhans cell histiocytosis
KW - fibula-free flap
KW - malignancy
KW - mandible reconstruction
KW - mandibulectomy
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U2 - 10.1097/SCS.0000000000005925
DO - 10.1097/SCS.0000000000005925
M3 - Article
C2 - 31634312
AN - SCOPUS:85077297268
SN - 1049-2275
VL - 31
SP - e70-e73
JO - Journal of Craniofacial Surgery
JF - Journal of Craniofacial Surgery
IS - 1
ER -