Langerhans Cell Histiocytosis in an Adult: A Discussion of Epidemiology and Treatment Options

Kaley K. El-Arab, Alexis Inge Luedke, Bao Quynh Thuy Julian, Julie Ferrauiola, Frank Raymond Miller, Howard Tz Ho Wang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Langerhans cell histiocytosis (LCH) is a rare disorder defined by the abnormal proliferation of Langerhans cells. While LCH can present at any age, it is classically described as a pediatric condition, and is therefore overlooked in the adult patient. Additionally, depending on tumor burden and location, LCH can manifest with a host of oral and systemic symptoms which further confuses the clinical presentation and ultimate diagnosis.The authors present a unique report of an elderly Hispanic male diagnosed with mandibular LCH who sought primary tumor excision after neoadjuvant chemotherapy. In this study, a fibula-free flap was used for subsequent reconstruction.The purpose of the study is 2-fold: To highlight the variability of LCH in both patient symptomatology and demographics, as well as the role of plastic reconstructive surgery in definitive LCH management, particularly in the setting of single system unifocal disease.

Original languageEnglish (US)
Pages (from-to)e70-e73
JournalJournal of Craniofacial Surgery
Issue number1
StatePublished - Jan 1 2020


  • Bone lesion
  • Langerhans cell histiocytosis
  • fibula-free flap
  • malignancy
  • mandible reconstruction
  • mandibulectomy

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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