Serum and gastric juice lactic dehydrogenase (LD) activity has been measured in patients with normal stomachs, with uncomplicated pernicious anemia, with benign gastric ulcer, and with gastric cancer. The measurements were made of specimens containing no free hydrochloric acid. The results of these preliminary studies suggest that the determination of LD activity in gastric juice may be helpful in the diagnosis of gastric cancer. Gastric LD activity appears to be independent of serum LD activity. Further research, especially concerning the relationship of gastric mucosal changes and gastric LD activity, is recommended.
ASJC Scopus subject areas