Lactate Elicits ER-Mitochondrial Mg2+ Dynamics to Integrate Cellular Metabolism

Cassidy C. Daw; Karthik Ramachandran; Benjamin T. Enslow; Soumya Maity; Brian Bursic; Matthew J. Novello; Cherubina S. Rubannelsonkumar; Ayah H. Mashal; Joel Ravichandran; Terry M. Bakewell; Weiwei Wang; Kang Li; Travis R. Madaris; Christopher E. Shannon; Luke Norton; Soundarya Kandala; Jeffrey Caplan; Subramanya Srikantan; Peter B. Stathopulos; W. Brian Reeves; Muniswamy Madesh

doi:10.1016/j.cell.2020.08.049

Lactate Elicits ER-Mitochondrial Mg²⁺ Dynamics to Integrate Cellular Metabolism

Cassidy C. Daw
, Karthik Ramachandran
, Benjamin T. Enslow
, Soumya Maity
, Brian Bursic
, Matthew J. Novello
, Cherubina S. Rubannelsonkumar
, Ayah H. Mashal
, Joel Ravichandran
, Terry M. Bakewell
, Weiwei Wang
, Kang Li
, Travis R. Madaris
, Christopher E. Shannon
, Luke Norton
, Soundarya Kandala
, Jeffrey Caplan
, Subramanya Srikantan
, Peter B. Stathopulos
, W. Brian Reeves

Muniswamy Madesh

Research output: Contribution to journal › Article › peer-review

201 Scopus citations

Abstract

Lactate operates as a signaling molecule to control Mg²⁺ handling between the ER and mitochondria.

Original language	English (US)
Pages (from-to)	474-489.e17
Journal	Cell
Volume	183
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2020.08.049
State	Published - Oct 15 2020

Keywords

Mrs2
calcium
cancer
channel
endoplasmic reticulum
inflammation
lactate
magnesium
metabolism
mitochondria

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.cell.2020.08.049

Cite this

Daw, C. C., Ramachandran, K., Enslow, B. T., Maity, S., Bursic, B., Novello, M. J., Rubannelsonkumar, C. S., Mashal, A. H., Ravichandran, J., Bakewell, T. M., Wang, W., Li, K., Madaris, T. R., Shannon, C. E., Norton, L., Kandala, S., Caplan, J., Srikantan, S., Stathopulos, P. B., ... Madesh, M. (2020). Lactate Elicits ER-Mitochondrial Mg²⁺ Dynamics to Integrate Cellular Metabolism. Cell, 183(2), 474-489.e17. https://doi.org/10.1016/j.cell.2020.08.049

Daw, CC, Ramachandran, K, Enslow, BT, Maity, S, Bursic, B, Novello, MJ, Rubannelsonkumar, CS, Mashal, AH, Ravichandran, J, Bakewell, TM, Wang, W, Li, K, Madaris, TR, Shannon, CE, Norton, L, Kandala, S, Caplan, J, Srikantan, S, Stathopulos, PB, Reeves, WB & Madesh, M 2020, 'Lactate Elicits ER-Mitochondrial Mg²⁺ Dynamics to Integrate Cellular Metabolism', Cell, vol. 183, no. 2, pp. 474-489.e17. https://doi.org/10.1016/j.cell.2020.08.049

@article{f48e838458b24bbbb9341a5f5414d293,

title = "Lactate Elicits ER-Mitochondrial Mg2+ Dynamics to Integrate Cellular Metabolism",

abstract = "Lactate operates as a signaling molecule to control Mg2+ handling between the ER and mitochondria.",

keywords = "Mrs2, calcium, cancer, channel, endoplasmic reticulum, inflammation, lactate, magnesium, metabolism, mitochondria",

author = "Daw, \{Cassidy C.\} and Karthik Ramachandran and Enslow, \{Benjamin T.\} and Soumya Maity and Brian Bursic and Novello, \{Matthew J.\} and Rubannelsonkumar, \{Cherubina S.\} and Mashal, \{Ayah H.\} and Joel Ravichandran and Bakewell, \{Terry M.\} and Weiwei Wang and Kang Li and Madaris, \{Travis R.\} and Shannon, \{Christopher E.\} and Luke Norton and Soundarya Kandala and Jeffrey Caplan and Subramanya Srikantan and Stathopulos, \{Peter B.\} and Reeves, \{W. Brian\} and Muniswamy Madesh",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = oct,

day = "15",

doi = "10.1016/j.cell.2020.08.049",

language = "English (US)",

volume = "183",

pages = "474--489.e17",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Lactate Elicits ER-Mitochondrial Mg2+ Dynamics to Integrate Cellular Metabolism

AU - Daw, Cassidy C.

AU - Ramachandran, Karthik

AU - Enslow, Benjamin T.

AU - Maity, Soumya

AU - Bursic, Brian

AU - Novello, Matthew J.

AU - Rubannelsonkumar, Cherubina S.

AU - Mashal, Ayah H.

AU - Ravichandran, Joel

AU - Bakewell, Terry M.

AU - Wang, Weiwei

AU - Li, Kang

AU - Madaris, Travis R.

AU - Shannon, Christopher E.

AU - Norton, Luke

AU - Kandala, Soundarya

AU - Caplan, Jeffrey

AU - Srikantan, Subramanya

AU - Stathopulos, Peter B.

AU - Reeves, W. Brian

AU - Madesh, Muniswamy

PY - 2020/10/15

Y1 - 2020/10/15

N2 - Lactate operates as a signaling molecule to control Mg2+ handling between the ER and mitochondria.

AB - Lactate operates as a signaling molecule to control Mg2+ handling between the ER and mitochondria.

KW - Mrs2

KW - calcium

KW - cancer

KW - channel

KW - endoplasmic reticulum

KW - inflammation

KW - lactate

KW - magnesium

KW - metabolism

KW - mitochondria

UR - https://www.scopus.com/pages/publications/85092447278

UR - https://www.scopus.com/pages/publications/85092447278#tab=citedBy

U2 - 10.1016/j.cell.2020.08.049

DO - 10.1016/j.cell.2020.08.049

M3 - Article

C2 - 33035451

AN - SCOPUS:85092447278

SN - 0092-8674

VL - 183

SP - 474-489.e17

JO - Cell

JF - Cell

IS - 2

ER -