Lactate Elicits ER-Mitochondrial Mg2+ Dynamics to Integrate Cellular Metabolism

Cassidy C. Daw; Karthik Ramachandran; Benjamin T. Enslow; Soumya Maity; Brian Bursic; Matthew J. Novello; Cherubina S. Rubannelsonkumar; Ayah H. Mashal; Joel Ravichandran; Terry M. Bakewell; Weiwei Wang; Kang Li; Travis R. Madaris; Christopher E. Shannon; Luke Norton; Soundarya Kandala; Jeffrey Caplan; Subramanya Srikantan; Peter B. Stathopulos; W. Brian Reeves; Muniswamy Madesh

doi:10.1016/j.cell.2020.08.049

Lactate Elicits ER-Mitochondrial Mg²⁺ Dynamics to Integrate Cellular Metabolism

Cassidy C. Daw, Karthik Ramachandran, Benjamin T. Enslow, Soumya Maity, Brian Bursic, Matthew J. Novello, Cherubina S. Rubannelsonkumar, Ayah H. Mashal, Joel Ravichandran, Terry M. Bakewell, Weiwei Wang, Kang Li, Travis R. Madaris, Christopher E. Shannon, Luke Norton, Soundarya Kandala, Jeffrey Caplan, Subramanya Srikantan, Peter B. Stathopulos, W. Brian ReevesMuniswamy Madesh

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

Lactate operates as a signaling molecule to control Mg²⁺ handling between the ER and mitochondria.

Original language	English (US)
Pages (from-to)	474-489.e17
Journal	Cell
Volume	183
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2020.08.049
State	Published - Oct 15 2020

Keywords

Mrs2
calcium
cancer
channel
endoplasmic reticulum
inflammation
lactate
magnesium
metabolism
mitochondria

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.cell.2020.08.049

Cite this

Daw, C. C., Ramachandran, K., Enslow, B. T., Maity, S., Bursic, B., Novello, M. J., Rubannelsonkumar, C. S., Mashal, A. H., Ravichandran, J., Bakewell, T. M., Wang, W., Li, K., Madaris, T. R., Shannon, C. E., Norton, L., Kandala, S., Caplan, J., Srikantan, S., Stathopulos, P. B., ... Madesh, M. (2020). Lactate Elicits ER-Mitochondrial Mg²⁺ Dynamics to Integrate Cellular Metabolism. Cell, 183(2), 474-489.e17. https://doi.org/10.1016/j.cell.2020.08.049

Daw, CC, Ramachandran, K, Enslow, BT, Maity, S, Bursic, B, Novello, MJ, Rubannelsonkumar, CS, Mashal, AH, Ravichandran, J, Bakewell, TM, Wang, W, Li, K, Madaris, TR, Shannon, CE, Norton, L, Kandala, S, Caplan, J, Srikantan, S, Stathopulos, PB, Reeves, WB & Madesh, M 2020, 'Lactate Elicits ER-Mitochondrial Mg²⁺ Dynamics to Integrate Cellular Metabolism', Cell, vol. 183, no. 2, pp. 474-489.e17. https://doi.org/10.1016/j.cell.2020.08.049

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abstract = "Lactate operates as a signaling molecule to control Mg2+ handling between the ER and mitochondria.",

keywords = "Mrs2, calcium, cancer, channel, endoplasmic reticulum, inflammation, lactate, magnesium, metabolism, mitochondria",

author = "Daw, \{Cassidy C.\} and Karthik Ramachandran and Enslow, \{Benjamin T.\} and Soumya Maity and Brian Bursic and Novello, \{Matthew J.\} and Rubannelsonkumar, \{Cherubina S.\} and Mashal, \{Ayah H.\} and Joel Ravichandran and Bakewell, \{Terry M.\} and Weiwei Wang and Kang Li and Madaris, \{Travis R.\} and Shannon, \{Christopher E.\} and Luke Norton and Soundarya Kandala and Jeffrey Caplan and Subramanya Srikantan and Stathopulos, \{Peter B.\} and Reeves, \{W. Brian\} and Muniswamy Madesh",

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AU - Bursic, Brian

AU - Novello, Matthew J.

AU - Rubannelsonkumar, Cherubina S.

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AU - Bakewell, Terry M.

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KW - magnesium

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