Lactate Elicits ER-Mitochondrial Mg2+ Dynamics to Integrate Cellular Metabolism

Cassidy C. Daw, Karthik Ramachandran, Benjamin T. Enslow, Soumya Maity, Brian Bursic, Matthew J. Novello, Cherubina S. Rubannelsonkumar, Ayah H. Mashal, Joel Ravichandran, Terry M. Bakewell, Weiwei Wang, Kang Li, Travis R. Madaris, Christopher E. Shannon, Luke Norton, Soundarya Kandala, Jeffrey Caplan, Subramanya Srikantan, Peter B. Stathopulos, W. Brian ReevesMuniswamy Madesh

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


Lactate operates as a signaling molecule to control Mg2+ handling between the ER and mitochondria.

Original languageEnglish (US)
Pages (from-to)474-489.e17
Issue number2
StatePublished - Oct 15 2020


  • Mrs2
  • calcium
  • cancer
  • channel
  • endoplasmic reticulum
  • inflammation
  • lactate
  • magnesium
  • metabolism
  • mitochondria

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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