Lacosamide induced Brugada I morphology in the setting of septicemia: A case report

Robert Goodnough, Adina Badea, Curtis Geier, Kara L. Lynch, Kathy T. Lesaint

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Introduction:Brugada syndrome may be unmasked by non-antiarrhythmic pharmaceuticals or drugs. Lacosamide is an antiepileptic agent with a novel mechanism of sodium channel inhibition and has the potential to cause cardiac sodium channel blockade.Patient concerns:In this report, we describe the case of patient with a history of a seizure disorder who presented with Brugada I electrocardiogram morphology in the setting of septicemia.Diagnosis:Brugada I electrocardiogram morphology was unmasked by lacosamide antiepileptic monotherapy.Interventions:Lacosamide therapy was discontinued.Outcomes:Normalization of the electrocardiogram and resolution of Brugada morphology occurred on hospital day 1.Conclusion:Caution should be exercised in the use of lacosamide in those at risk for conduction delay, or in combination therapy with medications that impair renal clearance, metabolism of lacosamide, or that display inherent sodium channel blocking properties.

Original languageEnglish (US)
Pages (from-to)E25577
JournalMedicine (United States)
Volume100
Issue number18
DOIs
StatePublished - May 7 2021
Externally publishedYes

Keywords

  • Brugada
  • lacosamide

ASJC Scopus subject areas

  • General Medicine

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