Lack of susceptibility of baboons to infection with hepatitis B virus

Marian G. Michaels, Robert Lanford, Anthony J. Demetris, Deborah Chavez, Kathleen Brasky, John Fung, Thomas E. Starzl

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Historically, hepatitis B virus (HBV) has been considered species specific and unable to infect baboons. Based on this premise, two patients with HBV end-stage liver disease underwent baboon liver xenotransplantation. To study whether baboons are susceptible to HBV infection, four baboons (two receiving immunosuppressive therapy) were inoculated with HBV. Animals were followed for 6 months: clinical examinations and biochemical studies were normal, hepatitis B surface antigen and hepatitis B core antigen staining of biopsies was negative, and HBV serology remained negative. HBV polymerase chain reaction was transiently positive in one animal, which most likely reflects the initial inoculation. This pilot study corroborates historical evidence and beliefs that baboons are resistant to HBV.

Original languageEnglish (US)
Pages (from-to)350-351
Number of pages2
JournalTransplantation
Volume61
Issue number3
StatePublished - Feb 15 1996
Externally publishedYes

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Papio
Hepatitis B virus
Infection
Hepatitis B Core Antigens
Heterologous Transplantation
End Stage Liver Disease
Virus Diseases
Serology
Immunosuppressive Agents
Hepatitis B Surface Antigens
Staining and Labeling
Biopsy
Polymerase Chain Reaction
Liver

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Michaels, M. G., Lanford, R., Demetris, A. J., Chavez, D., Brasky, K., Fung, J., & Starzl, T. E. (1996). Lack of susceptibility of baboons to infection with hepatitis B virus. Transplantation, 61(3), 350-351.

Lack of susceptibility of baboons to infection with hepatitis B virus. / Michaels, Marian G.; Lanford, Robert; Demetris, Anthony J.; Chavez, Deborah; Brasky, Kathleen; Fung, John; Starzl, Thomas E.

In: Transplantation, Vol. 61, No. 3, 15.02.1996, p. 350-351.

Research output: Contribution to journalArticle

Michaels, MG, Lanford, R, Demetris, AJ, Chavez, D, Brasky, K, Fung, J & Starzl, TE 1996, 'Lack of susceptibility of baboons to infection with hepatitis B virus', Transplantation, vol. 61, no. 3, pp. 350-351.
Michaels MG, Lanford R, Demetris AJ, Chavez D, Brasky K, Fung J et al. Lack of susceptibility of baboons to infection with hepatitis B virus. Transplantation. 1996 Feb 15;61(3):350-351.
Michaels, Marian G. ; Lanford, Robert ; Demetris, Anthony J. ; Chavez, Deborah ; Brasky, Kathleen ; Fung, John ; Starzl, Thomas E. / Lack of susceptibility of baboons to infection with hepatitis B virus. In: Transplantation. 1996 ; Vol. 61, No. 3. pp. 350-351.
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