Lack of pineal-induced gonadal regression in dark-exposed or blind hamsters after surgical isolation of the medial-basal hypothalamus

Sandy Sorrentino, Russel J Reiter

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7 Citations (Scopus)

Abstract

Blinding or exposing hamsters to increased dark periods (L:D::1:23) caused involution of the reproductive organs. Involution of reproductive organs was absent in hamsters that were pinealectomized or subjected to complete surgical isolation of the medial-basal hypothalamus. This observation suggests that isolation of the medial-basal hypothalamus may have destroyed pathways which serve to transmit photic information to the pineal (e.g., medial forebrain bundle) or the site of action of the substance secreted by the pineal in blind or dark-exposed hamsters is outside of the cut, located in a neural structure responsible for inhibition of gonadotropin release.

Original languageEnglish (US)
Pages (from-to)227-231
Number of pages5
JournalGeneral and Comparative Endocrinology
Volume17
Issue number1
DOIs
StatePublished - 1971
Externally publishedYes

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Middle Hypothalamus
hypothalamus
hamsters
Cricetinae
gonads
gonadotropin release
Medial Forebrain Bundle
scotophase
Gonadotropins
brain

ASJC Scopus subject areas

  • Endocrinology

Cite this

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abstract = "Blinding or exposing hamsters to increased dark periods (L:D::1:23) caused involution of the reproductive organs. Involution of reproductive organs was absent in hamsters that were pinealectomized or subjected to complete surgical isolation of the medial-basal hypothalamus. This observation suggests that isolation of the medial-basal hypothalamus may have destroyed pathways which serve to transmit photic information to the pineal (e.g., medial forebrain bundle) or the site of action of the substance secreted by the pineal in blind or dark-exposed hamsters is outside of the cut, located in a neural structure responsible for inhibition of gonadotropin release.",
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T1 - Lack of pineal-induced gonadal regression in dark-exposed or blind hamsters after surgical isolation of the medial-basal hypothalamus

AU - Sorrentino, Sandy

AU - Reiter, Russel J

PY - 1971

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N2 - Blinding or exposing hamsters to increased dark periods (L:D::1:23) caused involution of the reproductive organs. Involution of reproductive organs was absent in hamsters that were pinealectomized or subjected to complete surgical isolation of the medial-basal hypothalamus. This observation suggests that isolation of the medial-basal hypothalamus may have destroyed pathways which serve to transmit photic information to the pineal (e.g., medial forebrain bundle) or the site of action of the substance secreted by the pineal in blind or dark-exposed hamsters is outside of the cut, located in a neural structure responsible for inhibition of gonadotropin release.

AB - Blinding or exposing hamsters to increased dark periods (L:D::1:23) caused involution of the reproductive organs. Involution of reproductive organs was absent in hamsters that were pinealectomized or subjected to complete surgical isolation of the medial-basal hypothalamus. This observation suggests that isolation of the medial-basal hypothalamus may have destroyed pathways which serve to transmit photic information to the pineal (e.g., medial forebrain bundle) or the site of action of the substance secreted by the pineal in blind or dark-exposed hamsters is outside of the cut, located in a neural structure responsible for inhibition of gonadotropin release.

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