Lack of extrapyramidal side effects predicts quality of life in outpatients treated with clozapine or with typical antipsychotics

Sergio A. Strejilevich, Ana Palatnik, Rubén Avila, Julián Bustin, Julieta Cassone, Soledad Figueroa, Mariana Gimenez, Gabriel A. De Erausquin

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

We compared symptom severity and quality of life (QOL) in schizophrenic patients adequately treated with typical antipsychotics (TAP) or clozapine (CZP). Groups did not differ in symptom severity or QOL. Clozapine caused fewer extrapyramidal symptoms. Negative and extrapyramidal symptoms predicted QOL. Similar outcome in both groups suggests a common ceiling to antipsychotic efficacy.

Original languageEnglish (US)
Pages (from-to)277-280
Number of pages4
JournalPsychiatry Research
Volume133
Issue number2-3
DOIs
StatePublished - Feb 28 2005
Externally publishedYes

Keywords

  • Negative symptoms
  • Parkinsonism
  • Treatment outcome

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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