Lack of extrapyramidal side effects predicts quality of life in outpatients treated with clozapine or with typical antipsychotics

Sergio A. Strejilevich; Ana Palatnik; Rubén Avila; Julián Bustin; Julieta Cassone; Soledad Figueroa; Mariana Gimenez; Gabriel A. De Erausquin

doi:10.1016/j.psychres.2004.10.009

Lack of extrapyramidal side effects predicts quality of life in outpatients treated with clozapine or with typical antipsychotics

Sergio A. Strejilevich, Ana Palatnik, Rubén Avila, Julián Bustin, Julieta Cassone, Soledad Figueroa, Mariana Gimenez, Gabriel A. De Erausquin

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

We compared symptom severity and quality of life (QOL) in schizophrenic patients adequately treated with typical antipsychotics (TAP) or clozapine (CZP). Groups did not differ in symptom severity or QOL. Clozapine caused fewer extrapyramidal symptoms. Negative and extrapyramidal symptoms predicted QOL. Similar outcome in both groups suggests a common ceiling to antipsychotic efficacy.

Original language	English (US)
Pages (from-to)	277-280
Number of pages	4
Journal	Psychiatry Research
Volume	133
Issue number	2-3
DOIs	https://doi.org/10.1016/j.psychres.2004.10.009
State	Published - Feb 28 2005
Externally published	Yes

Keywords

Negative symptoms
Parkinsonism
Treatment outcome

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psychres.2004.10.009

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abstract = "We compared symptom severity and quality of life (QOL) in schizophrenic patients adequately treated with typical antipsychotics (TAP) or clozapine (CZP). Groups did not differ in symptom severity or QOL. Clozapine caused fewer extrapyramidal symptoms. Negative and extrapyramidal symptoms predicted QOL. Similar outcome in both groups suggests a common ceiling to antipsychotic efficacy.",

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AU - Strejilevich, Sergio A.

AU - Palatnik, Ana

AU - Avila, Rubén

AU - Bustin, Julián

AU - Cassone, Julieta

AU - Figueroa, Soledad

AU - Gimenez, Mariana

AU - De Erausquin, Gabriel A.

PY - 2005/2/28

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AB - We compared symptom severity and quality of life (QOL) in schizophrenic patients adequately treated with typical antipsychotics (TAP) or clozapine (CZP). Groups did not differ in symptom severity or QOL. Clozapine caused fewer extrapyramidal symptoms. Negative and extrapyramidal symptoms predicted QOL. Similar outcome in both groups suggests a common ceiling to antipsychotic efficacy.

KW - Negative symptoms

KW - Parkinsonism

KW - Treatment outcome

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Lack of extrapyramidal side effects predicts quality of life in outpatients treated with clozapine or with typical antipsychotics

Abstract

Keywords

ASJC Scopus subject areas

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