Lack of evidence for a major gene in the mendelian transmission of BMI in Chinese

Peng Yuan Liu; Yu Mei Li; Miao Xin Li; Ida Malkin; Yue Juan Qin; Xiang Ding Chen; Yong Jun Liu; Hong Wen Deng

doi:10.1038/oby.2004.247

Lack of evidence for a major gene in the mendelian transmission of BMI in Chinese

Peng Yuan Liu
, Yu Mei Li
, Miao Xin Li
, Ida Malkin
, Yue Juan Qin
, Xiang Ding Chen
, Yong Jun Liu
, Hong Wen Deng

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Objectives: To determine the heritability of BMI and to examine the mode of inheritance of BMI variation in Chinese. Research Methods and Procedures: Familial correlation and complex segregation analyses for BMI were undertaken in a Chinese sample composed of 392 nuclear families, with 1190 total individuals. Results: A moderate heritability was found for BMI (h² = 0.419-0.492). The obtained results do not support a ajor gene for BMI in our samples. BMI may be inherited in a complex and non-Mendelian manner in Chinese. Discussion: The findings of this study suggest that identification of specific genes for BMI in Chinese, at least within the same data set, is a serious challenge because of the lack of evidence of a major gene for BMI in our Chinese sample.

Original language	English (US)
Pages (from-to)	1967-1973
Number of pages	7
Journal	Obesity Research
Volume	12
Issue number	12
DOIs	https://doi.org/10.1038/oby.2004.247
State	Published - Dec 2004
Externally published	Yes

Keywords

BMI
Chinese population
Familial correlation
Major genes
Segregation analysis

ASJC Scopus subject areas

Medicine (miscellaneous)
Food Science
Endocrinology, Diabetes and Metabolism
Endocrinology
Public Health, Environmental and Occupational Health

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10.1038/oby.2004.247

Cite this

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title = "Lack of evidence for a major gene in the mendelian transmission of BMI in Chinese",

abstract = "Objectives: To determine the heritability of BMI and to examine the mode of inheritance of BMI variation in Chinese. Research Methods and Procedures: Familial correlation and complex segregation analyses for BMI were undertaken in a Chinese sample composed of 392 nuclear families, with 1190 total individuals. Results: A moderate heritability was found for BMI (h2 = 0.419-0.492). The obtained results do not support a ajor gene for BMI in our samples. BMI may be inherited in a complex and non-Mendelian manner in Chinese. Discussion: The findings of this study suggest that identification of specific genes for BMI in Chinese, at least within the same data set, is a serious challenge because of the lack of evidence of a major gene for BMI in our Chinese sample.",

keywords = "BMI, Chinese population, Familial correlation, Major genes, Segregation analysis",

author = "Liu, \{Peng Yuan\} and Li, \{Yu Mei\} and Li, \{Miao Xin\} and Ida Malkin and Qin, \{Yue Juan\} and Chen, \{Xiang Ding\} and Liu, \{Yong Jun\} and Deng, \{Hong Wen\}",

year = "2004",

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T1 - Lack of evidence for a major gene in the mendelian transmission of BMI in Chinese

AU - Liu, Peng Yuan

AU - Li, Yu Mei

AU - Li, Miao Xin

AU - Malkin, Ida

AU - Qin, Yue Juan

AU - Chen, Xiang Ding

AU - Liu, Yong Jun

AU - Deng, Hong Wen

PY - 2004/12

Y1 - 2004/12

N2 - Objectives: To determine the heritability of BMI and to examine the mode of inheritance of BMI variation in Chinese. Research Methods and Procedures: Familial correlation and complex segregation analyses for BMI were undertaken in a Chinese sample composed of 392 nuclear families, with 1190 total individuals. Results: A moderate heritability was found for BMI (h2 = 0.419-0.492). The obtained results do not support a ajor gene for BMI in our samples. BMI may be inherited in a complex and non-Mendelian manner in Chinese. Discussion: The findings of this study suggest that identification of specific genes for BMI in Chinese, at least within the same data set, is a serious challenge because of the lack of evidence of a major gene for BMI in our Chinese sample.

AB - Objectives: To determine the heritability of BMI and to examine the mode of inheritance of BMI variation in Chinese. Research Methods and Procedures: Familial correlation and complex segregation analyses for BMI were undertaken in a Chinese sample composed of 392 nuclear families, with 1190 total individuals. Results: A moderate heritability was found for BMI (h2 = 0.419-0.492). The obtained results do not support a ajor gene for BMI in our samples. BMI may be inherited in a complex and non-Mendelian manner in Chinese. Discussion: The findings of this study suggest that identification of specific genes for BMI in Chinese, at least within the same data set, is a serious challenge because of the lack of evidence of a major gene for BMI in our Chinese sample.

KW - BMI

KW - Chinese population

KW - Familial correlation

KW - Major genes

KW - Segregation analysis

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JO - Obesity Research

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Lack of evidence for a major gene in the mendelian transmission of BMI in Chinese

Abstract

Keywords

ASJC Scopus subject areas

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