Lack of evidence for a major gene in the mendelian transmission of BMI in Chinese

Peng Yuan Liu, Yu Mei Li, Miao Xin Li, Ida Malkin, Yue Juan Qin, Xiang Ding Chen, Yong Jun Liu, Hong Wen Deng

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Objectives: To determine the heritability of BMI and to examine the mode of inheritance of BMI variation in Chinese. Research Methods and Procedures: Familial correlation and complex segregation analyses for BMI were undertaken in a Chinese sample composed of 392 nuclear families, with 1190 total individuals. Results: A moderate heritability was found for BMI (h2 = 0.419-0.492). The obtained results do not support a ajor gene for BMI in our samples. BMI may be inherited in a complex and non-Mendelian manner in Chinese. Discussion: The findings of this study suggest that identification of specific genes for BMI in Chinese, at least within the same data set, is a serious challenge because of the lack of evidence of a major gene for BMI in our Chinese sample.

Original languageEnglish (US)
Pages (from-to)1967-1973
Number of pages7
JournalObesity Research
Issue number12
StatePublished - Dec 2004
Externally publishedYes


  • BMI
  • Chinese population
  • Familial correlation
  • Major genes
  • Segregation analysis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Public Health, Environmental and Occupational Health


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