Abstract
Objectives: To determine the heritability of BMI and to examine the mode of inheritance of BMI variation in Chinese. Research Methods and Procedures: Familial correlation and complex segregation analyses for BMI were undertaken in a Chinese sample composed of 392 nuclear families, with 1190 total individuals. Results: A moderate heritability was found for BMI (h2 = 0.419-0.492). The obtained results do not support a ajor gene for BMI in our samples. BMI may be inherited in a complex and non-Mendelian manner in Chinese. Discussion: The findings of this study suggest that identification of specific genes for BMI in Chinese, at least within the same data set, is a serious challenge because of the lack of evidence of a major gene for BMI in our Chinese sample.
Original language | English (US) |
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Pages (from-to) | 1967-1973 |
Number of pages | 7 |
Journal | Obesity Research |
Volume | 12 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2004 |
Externally published | Yes |
Keywords
- BMI
- Chinese population
- Familial correlation
- Major genes
- Segregation analysis
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Food Science
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Public Health, Environmental and Occupational Health