TY - JOUR
T1 - Lack of Effect of Pinealectomy on Ovarian Function
T2 - Evidence for a Time-Dependent Action
AU - Defronzo, Ralph A.
AU - Roth, Willard D.
N1 - Funding Information:
Supported in part by U.S. Public Health Service Grant 5RO1 AM 12425 and the John L. Larkin Award. 2
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1971/12
Y1 - 1971/12
N2 - The interrelationship between the rat pineal, ovary, and hypophysis was examined utilizing organ weight, histology, RNA content, and RNA:DNA ratio as an index of synthetic activity. Six weeks post-pinealectomy, no change in ovarian function was observed utilizing the above parameters. A time-dependent action of pinealectomy on ovarian activity is postulated. Following ovariectomy a significant increase in pineal weight was seen. This suggests the existence of a feedback mechanism between the pineal and anterior pituitary similar to that of other endocrine organs.
AB - The interrelationship between the rat pineal, ovary, and hypophysis was examined utilizing organ weight, histology, RNA content, and RNA:DNA ratio as an index of synthetic activity. Six weeks post-pinealectomy, no change in ovarian function was observed utilizing the above parameters. A time-dependent action of pinealectomy on ovarian activity is postulated. Following ovariectomy a significant increase in pineal weight was seen. This suggests the existence of a feedback mechanism between the pineal and anterior pituitary similar to that of other endocrine organs.
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U2 - 10.3181/00379727-138-36049
DO - 10.3181/00379727-138-36049
M3 - Article
C2 - 5131605
AN - SCOPUS:0015185750
SN - 0037-9727
VL - 138
SP - 1058
EP - 1061
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 3
ER -