Lack of Effect of Pinealectomy on Ovarian Function: Evidence for a Time-Dependent Action

Ralph A. Defronzo, Willard D. Roth

Research output: Contribution to journalArticle

Abstract

The interrelationship between the rat pineal, ovary, and hypophysis was examined utilizing organ weight, histology, RNA content, and RNA:DNA ratio as an index of synthetic activity. Six weeks post-pinealectomy, no change in ovarian function was observed utilizing the above parameters. A time-dependent action of pinealectomy on ovarian activity is postulated. Following ovariectomy a significant increase in pineal weight was seen. This suggests the existence of a feedback mechanism between the pineal and anterior pituitary similar to that of other endocrine organs.

Original languageEnglish (US)
Pages (from-to)1058-1061
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume138
Issue number3
DOIs
StatePublished - Dec 1971
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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