Lack of effect of nizatidine on hepatic drug metabolism in man.

JW Secor; KV Speeg; CG Meredith; RF Johnson; P. Snowdy; S. Schenker

doi:10.1111/j.1365-2125.1985.tb05136.x

Lack of effect of nizatidine on hepatic drug metabolism in man.

JW Secor, KV Speeg, CG Meredith, RF Johnson, P. Snowdy, S. Schenker

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Abstract

The effect of nizatidine, a new H2‐receptor antagonist, on the hepatic metabolism of three probe drugs was studied in normal volunteers. The drugs studied were chlordiazepoxide and theophylline which are metabolized in part by N‐demethylation by the hepatic microsomal cytochrome P‐450 system and lorazepam which is conjugated to lorazepam glucuronide. A 7 day course of nizatidine did not interfere with the disposition of any of these therapeutic agents in man. 1985 The British Pharmacological Society

Original language	English (US)
Pages (from-to)	710-713
Number of pages	4
Journal	British Journal of Clinical Pharmacology
Volume	20
Issue number	6
DOIs	https://doi.org/10.1111/j.1365-2125.1985.tb05136.x
State	Published - Dec 1985

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1111/j.1365-2125.1985.tb05136.x

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AU - Speeg, KV

AU - Meredith, CG

AU - Johnson, RF

AU - Snowdy, P.

AU - Schenker, S.

PY - 1985/12

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AB - The effect of nizatidine, a new H2‐receptor antagonist, on the hepatic metabolism of three probe drugs was studied in normal volunteers. The drugs studied were chlordiazepoxide and theophylline which are metabolized in part by N‐demethylation by the hepatic microsomal cytochrome P‐450 system and lorazepam which is conjugated to lorazepam glucuronide. A 7 day course of nizatidine did not interfere with the disposition of any of these therapeutic agents in man. 1985 The British Pharmacological Society

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Lack of effect of nizatidine on hepatic drug metabolism in man.

Abstract

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