Lack of effect of lowering LDL cholesterol on cancer: Meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy

Jonathan R. Emberson, Patricia M. Kearney, Lisa Blackwell, Connie Newman, Christina Reith, Neeraj Bhala, Lisa Holland, Richard Peto, Anthony Keech, Rory Collins, John Simes, Colin Baigent, J. De Lemos, E. Braunwald, M. Blazing, S. Murphy, J. R. Downs, A. Gotto, M. Clearfield, H. HoldaasD. Gordon, B. Davis, M. Koren, B. Dahlof, N. Poulter, P. Sever, R. H. Knopp, B. Fellström, A. Jardine, R. Schmieder, F. Zannad, U. Goldbourt, E. Kaplinsky, H. M. Colhoun, D. J. Betteridge, P. N. Durrington, G. A. Hitman, J. Fuller, A. Neil, C. Wanner, V. Krane, F. Sacks, L. Moyé, M. Pfeffer, C. M. Hawkins, J. Kjekshus, H. Wedel, J. Wikstrand, L. Tavazzi, A. Maggioni, R. Marchioli, G. Tognoni, M. G. Franzosi, J. Armitage, S. Parish, P. Sleight, T. R. Pedersen, P. M. Ridker, S. MacMahon, I. Marschner, A. Tonkin, J. Shaw, P. W. Serruys, H. Nakamura, G. Knatterud, C. Furberg, R. Byington, P. Macfarlane, S. Cobbe, I. Ford, M. Murphy, G. J. Blauw, C. Packard, J. Shepherd, L. Wilhelmsen, C. Cannon, L. Bowman, J. La Rosa, M. Flather, J. Kastelein, C. Shear, J. Tobert, J. Varigos, H. White, S. Yusuf, A. Baxter, E. H. Barnes, G. Buck, W. G. Herrington, A. Kirby, D. A. Lewis, M. Mellies, M. McGovern, J. Barclay, R. Belder, Y. Mitchell, T. Musliner, J. C. Ansquer, M. Llewellyn, M. Bortolini, B. Bryzinski, G. Olsson, J. Pears, D. DeMicco

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Abstract

Background: Statin therapy reduces the risk of occlusive vascular events, but uncertainty remains about potential effects on cancer. We sought to provide a detailed assessment of any effects on cancer of lowering LDL cholesterol (LDL-C) with a statin using individual patient records from 175,000 patients in 27 large-scale statin trials. Methods and Findings: Individual records of 134,537 participants in 22 randomised trials of statin versus control (median duration 4.8 years) and 39,612 participants in 5 trials of more intensive versus less intensive statin therapy (median duration 5.1 years) were obtained. Reducing LDL-C with a statin for about 5 years had no effect on newly diagnosed cancer or on death from such cancers in either the trials of statin versus control (cancer incidence: 3755 [1.4% per year [py]] versus 3738 [1.4% py], RR 1.00 [95% CI 0.96-1.05]; cancer mortality: 1365 [0.5% py] versus 1358 [0.5% py], RR 1.00 [95% CI 0.93-1.08]) or in the trials of more versus less statin (cancer incidence: 1466 [1.6% py] vs 1472 [1.6% py], RR 1.00 [95% CI 0.93-1.07]; cancer mortality: 447 [0.5% py] versus 481 [0.5% py], RR 0.93 [95% CI 0.82-1.06]). Moreover, there was no evidence of any effect of reducing LDL-C with statin therapy on cancer incidence or mortality at any of 23 individual categories of sites, with increasing years of treatment, for any individual statin, or in any given subgroup. In particular, among individuals with low baseline LDL-C (<2 mmol/L), there was no evidence that further LDL-C reduction (from about 1.7 to 1.3 mmol/L) increased cancer risk (381 [1.6% py] versus 408 [1.7% py]; RR 0.92 [99% CI 0.76-1.10]). Conclusions: In 27 randomised trials, a median of five years of statin therapy had no effect on the incidence of, or mortality from, any type of cancer (or the aggregate of all cancer).

Original languageEnglish (US)
Article numbere29849
JournalPloS one
Volume7
Issue number1
DOIs
StatePublished - Jan 19 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Emberson, J. R., Kearney, P. M., Blackwell, L., Newman, C., Reith, C., Bhala, N., Holland, L., Peto, R., Keech, A., Collins, R., Simes, J., Baigent, C., De Lemos, J., Braunwald, E., Blazing, M., Murphy, S., Downs, J. R., Gotto, A., Clearfield, M., ... DeMicco, D. (2012). Lack of effect of lowering LDL cholesterol on cancer: Meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy. PloS one, 7(1), [e29849]. https://doi.org/10.1371/journal.pone.0029849