Lack of effect of carbon monoxide inhibitor on relaxation induced by electrical field stimulation in corpus cavernosum

Y. C. Kim, M. G. Davies, L. Marson, P. O. Hagen, C. C. Carson

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Carbon monoxide has been proposed as a possible neurotransmitter because of its ability to bind to the iron atom of the heme of guanylyl cyclase, which is similar to that of nitric oxide. To determine whether carbon monoxide exerts an effect on the penis, strips of rabbit corpus cavernosum were mounted in an organ bath for isometric tension studies and the effect of zinc deuteroporphyrin, an inhibitor of heme oxygenase which metabolizes hemoprotein and releases carbon monoxide, on relaxation induced by electrical field stimulation (neurally mediated) was determined. Also observed was relaxation induced by electrical field stimulation after incubation with atropine and guanethidine to isolate nonadrenergic noncholinergic neurotransmission. Zinc deuteroporphyrin (10-6M, 10-5M, 10-4M and 3x10-4M) did not affect relaxation induced by electrical field stimulation in the absence or presence of guanethidine and atropine. Therefore, it appears that carbon monoxide does not contribute to neurally mediated relaxation of the rabbit corpus cavernosum.

Original languageEnglish (US)
Pages (from-to)291-293
Number of pages3
JournalUrological Research
Volume22
Issue number5
DOIs
StatePublished - Nov 1994
Externally publishedYes

Keywords

  • Carbon monoxide
  • Impotence
  • Rabbit corpus cavernosum

ASJC Scopus subject areas

  • Urology

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