Lack of association between sex hormones and Lp(a) concentrations in American and Finnish men

Steven M. Haffner, Leena Mykkanen, Katherine K. Gruber, David L. Rainwater, Markku Laakso

    Research output: Contribution to journalArticle

    24 Scopus citations

    Abstract

    Sex hormones may play a role in the determination of cardiovascular disease. Recently lipoprotein(a) (Lp[a]) has been recognized as a risk factor for coronary heart disease. Estrogens and anabolic steroids have been reported to alter Lp(a) levels, yet no data are available on the association between in vivo concentrations of sex hormones and Lp(a) concentrations. We examined the possible associations of sex hormone-binding globulin, total and free testosterone, estradiol, and dehydroepiandrosterone sulfate to Lp(a) concentrations in men in two population-based studies (San Antonio Heart Study [n=178] and a Finnish study on the association between insulin resistance and atherosclerosis [n=87]). In neither study were sex hormones significantly related to Lp(a) concentrations. In addition, Lp(a) was significantly related to apolipoprotein(a) molecular weight (which was measured in the Finnish study only). These results were unchanged when Lp(a) concentrations were adjusted for apolipoprotein(a) molecular weight (a strong correlate of Lp[a] concentrations). We conclude that in vivo concentrations of sex hormones are unlikely to be associated with Lp(a) concentrations in men.

    Original languageEnglish (US)
    Pages (from-to)19-24
    Number of pages6
    JournalArteriosclerosis, Thrombosis, and Vascular Biology
    Volume14
    Issue number1
    DOIs
    StatePublished - 1994

    Keywords

    • Lipoprotein(a)
    • Sex hormones

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

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