Lack of appreciation of the role of osmotically unresponsive water in cell volume regulation

Ivan L. Cameron, Gary D. Fullerton

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The osmotic responsiveness of cell water has been re-evaluated of reports on the osmotic behaviour of cells. In seven animal cell types, the osmotically unresponsive water (OUR) fraction values ranged from 0.75 to 2.41 g water/g dry mass (g/g), and from 25 to 92% of the total cell water. Protein confirmation, aggregation and crowding play a major, but under-recognised, role in determining the extent of OUR and the regulation of cell volume. Volume regulation studies that do not take into account the role of OUR must be judged incomplete.

Original languageEnglish (US)
Pages (from-to)610-614
Number of pages5
JournalCell Biology International
Volume38
Issue number5
DOIs
StatePublished - May 2014

Keywords

  • Cells
  • Osmosis
  • Volume regulation
  • Water

ASJC Scopus subject areas

  • Cell Biology

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