Lack of anxiety in an animal model of depression with cholinergic supersensitivity

Grant D. Schiller, Lynette C. Daws, David H. Overstreet, Joe Orbach

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


It has been suggested that anxiety and depression are correlated dimensions of behaviour. Consequently, this study investigated the behaviour of the Flinders Sensitive Line, an animal model of depression with cholinergic supersensitivity, in the elevated (+)-maze test of anxiety. The results indicate that anxiety responses (% open/total arm entries) do not differ between the Flinders Sensitive and Flinders Resistant (control) lines of rat (FSL vs. FRL, respectively). Treatment with 1.0 mg/kg of diazepam significantly increased % open/total scores to a similar degree in both lines, further suggesting that the lines do not differ in anxiety. It is concluded that the FSL rat is an animal model of depression without evidence for inherent alteration in anxiety-related behaviour.

Original languageEnglish (US)
Pages (from-to)433-435
Number of pages3
JournalBrain Research Bulletin
Issue number3
StatePublished - Mar 1991
Externally publishedYes


  • (+)-Maze
  • Animal model
  • Anxiety
  • Cholinergic supersensitivity
  • Depression
  • Diazepam
  • FSL and FRL rats

ASJC Scopus subject areas

  • Neuroscience(all)


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