Lack of an effect of zolmitriptan (Zomig, 311C90) on psychometric task performance: Results of a placebo-controlled study in healthy volunteers

A. J. Mercer, R. J. Lamb, P. E. Rolan, M. Gibbens, J. Posner

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The novel selective 5-hydroxytryptamine (5-HT)(1B/1D) agonist, zolmitriptan (Zomig, formerly known as 311C90), has shown good efficacy in the acute oral treatment of migraine. Zolmitriptan acts both centrally and peripherally, therefore it is important to assess central nervous system effects. At single doses of 25-50 mg (up to 8 times the likely therapeutic dose), zolmitriptan can cause sedation; therefore, a study was designed to examine the dose-response. A double-blind, randomized, placebo-controlled, six-limb crossover study in 13 healthy volunteers compared the effects of single oral doses of zolmitriptan (5,10,15 or 20 mg) and lorazepam (2 mg) on various psychometric tests. Zolmitriptan doses less than 20 mg had no statistically significant effects on choice reaction time, the Stroop test, visual analog scale (VAS) assessments of physical sedation, tranquilization and other types of feelings, the logical reasoning test or the adaptive tracking test. There was a mild transient increase in the subjective assessment on VAS of mental sedation which was dose related and occurred mainly with the highest zolmitriptan dose and were not reflected in objective measures of drug effects. In contrast, lorazepam (used as a positive control) was associated with statistically significant impairment in all tests (except tranquilization) for up to 10 h after dosing. The results demonstrate that therapeutic doses of zolmitriptan are unlikely to cause clinically significant impairment in psychometric performance.

Original languageEnglish (US)
Pages (from-to)398-404
Number of pages7
JournalPsychopharmacology
Volume140
Issue number4
DOIs
StatePublished - 1998
Externally publishedYes

Keywords

  • 311C90
  • Lorazepam
  • Migraine 5-HT(1B/1D) agonist
  • Psychometric performance
  • Zolmitriptan

ASJC Scopus subject areas

  • Pharmacology

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