Abstract
It is suggested that hepatic uptake of orally ingested glucose depends not only on insulin secretion but also on the release of a gastrointestinal factor which mediates insulin action on the liver. In maturity-onset diabetes characterised by hyper-insulinæmia and insulin resistance, deficiency of this gastrointestinal factor may be the primary pathogenetic event leading to postprandial hyperglycæmia. Postprandial hyperglycæmia brings about an increase in insulin secretion; and hyperinsulinæmia, in turn, results in decreased binding of insulin to its receptor and in peripheral (extrahepatic) resistance to insulin.
Original language | English (US) |
---|---|
Pages (from-to) | 1077-1079 |
Number of pages | 3 |
Journal | The Lancet |
Volume | 312 |
Issue number | 8099 |
DOIs | |
State | Published - Nov 18 1978 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)