LACK OF A GASTROINTESTINAL MEDIATOR OF INSULIN ACTION IN MATURITY-ONSET DIABETES

Ralph Defronzo, John Wahren, Eleuterio Ferrannini, Philip Felig

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

It is suggested that hepatic uptake of orally ingested glucose depends not only on insulin secretion but also on the release of a gastrointestinal factor which mediates insulin action on the liver. In maturity-onset diabetes characterised by hyper-insulinæmia and insulin resistance, deficiency of this gastrointestinal factor may be the primary pathogenetic event leading to postprandial hyperglycæmia. Postprandial hyperglycæmia brings about an increase in insulin secretion; and hyperinsulinæmia, in turn, results in decreased binding of insulin to its receptor and in peripheral (extrahepatic) resistance to insulin.

Original languageEnglish (US)
Pages (from-to)1077-1079
Number of pages3
JournalThe Lancet
Volume312
Issue number8099
DOIs
StatePublished - Nov 18 1978
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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