LACK OF A GASTROINTESTINAL MEDIATOR OF INSULIN ACTION IN MATURITY-ONSET DIABETES

Ralph Defronzo; John Wahren; Eleuterio Ferrannini; Philip Felig

doi:10.1016/S0140-6736(78)91807-X

LACK OF A GASTROINTESTINAL MEDIATOR OF INSULIN ACTION IN MATURITY-ONSET DIABETES

Ralph Defronzo, John Wahren, Eleuterio Ferrannini, Philip Felig

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

It is suggested that hepatic uptake of orally ingested glucose depends not only on insulin secretion but also on the release of a gastrointestinal factor which mediates insulin action on the liver. In maturity-onset diabetes characterised by hyper-insulinæmia and insulin resistance, deficiency of this gastrointestinal factor may be the primary pathogenetic event leading to postprandial hyperglycæmia. Postprandial hyperglycæmia brings about an increase in insulin secretion; and hyperinsulinæmia, in turn, results in decreased binding of insulin to its receptor and in peripheral (extrahepatic) resistance to insulin.

Original language	English (US)
Pages (from-to)	1077-1079
Number of pages	3
Journal	The Lancet
Volume	312
Issue number	8099
DOIs	https://doi.org/10.1016/S0140-6736(78)91807-X
State	Published - Nov 18 1978
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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title = "LACK OF A GASTROINTESTINAL MEDIATOR OF INSULIN ACTION IN MATURITY-ONSET DIABETES",

abstract = "It is suggested that hepatic uptake of orally ingested glucose depends not only on insulin secretion but also on the release of a gastrointestinal factor which mediates insulin action on the liver. In maturity-onset diabetes characterised by hyper-insulin{\ae}mia and insulin resistance, deficiency of this gastrointestinal factor may be the primary pathogenetic event leading to postprandial hyperglyc{\ae}mia. Postprandial hyperglyc{\ae}mia brings about an increase in insulin secretion; and hyperinsulin{\ae}mia, in turn, results in decreased binding of insulin to its receptor and in peripheral (extrahepatic) resistance to insulin.",

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AU - Felig, Philip

PY - 1978/11/18

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AB - It is suggested that hepatic uptake of orally ingested glucose depends not only on insulin secretion but also on the release of a gastrointestinal factor which mediates insulin action on the liver. In maturity-onset diabetes characterised by hyper-insulinæmia and insulin resistance, deficiency of this gastrointestinal factor may be the primary pathogenetic event leading to postprandial hyperglycæmia. Postprandial hyperglycæmia brings about an increase in insulin secretion; and hyperinsulinæmia, in turn, results in decreased binding of insulin to its receptor and in peripheral (extrahepatic) resistance to insulin.

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LACK OF A GASTROINTESTINAL MEDIATOR OF INSULIN ACTION IN MATURITY-ONSET DIABETES

Abstract

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