LACK OF A GASTROINTESTINAL MEDIATOR OF INSULIN ACTION IN MATURITY-ONSET DIABETES

Ralph A Defronzo, John Wahren, Eleuterio Ferrannini, Philip Felig

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

It is suggested that hepatic uptake of orally ingested glucose depends not only on insulin secretion but also on the release of a gastrointestinal factor which mediates insulin action on the liver. In maturity-onset diabetes characterised by hyper-insulinæmia and insulin resistance, deficiency of this gastrointestinal factor may be the primary pathogenetic event leading to postprandial hyperglycæmia. Postprandial hyperglycæmia brings about an increase in insulin secretion; and hyperinsulinæmia, in turn, results in decreased binding of insulin to its receptor and in peripheral (extrahepatic) resistance to insulin.

Original languageEnglish (US)
Pages (from-to)1077-1079
Number of pages3
JournalThe Lancet
Volume312
Issue number8099
DOIs
StatePublished - Nov 18 1978
Externally publishedYes

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Type 2 Diabetes Mellitus
Insulin
Liver
Vascular Resistance
Insulin Resistance
Glucose

ASJC Scopus subject areas

  • Medicine(all)

Cite this

LACK OF A GASTROINTESTINAL MEDIATOR OF INSULIN ACTION IN MATURITY-ONSET DIABETES. / Defronzo, Ralph A; Wahren, John; Ferrannini, Eleuterio; Felig, Philip.

In: The Lancet, Vol. 312, No. 8099, 18.11.1978, p. 1077-1079.

Research output: Contribution to journalArticle

Defronzo, Ralph A ; Wahren, John ; Ferrannini, Eleuterio ; Felig, Philip. / LACK OF A GASTROINTESTINAL MEDIATOR OF INSULIN ACTION IN MATURITY-ONSET DIABETES. In: The Lancet. 1978 ; Vol. 312, No. 8099. pp. 1077-1079.
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